Long-term follow up of subthalamic nucleus stimulation in Parkinson's disease

被引：112

作者：

Romito, LMA

Scerrati, M

Contarino, MF

Bentivoglio, AR

Tonali, P

Albanese, A

机构：

[1] Ist Nazl Neurol Carlo Besta, I-20133 Milan, Italy

[2] Univ Cattolica Sacro Cuore, Ist Neurochirurg, Rome, Italy

[3] Univ Cattolica Sacro Cuore, Ist Neurol, Rome, Italy

来源：

NEUROLOGY | 2002年 / 58卷 / 10期

关键词：

D O I：

10.1212/WNL.58.10.1546

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twenty-two patients with PD received bilateral implants for high frequency stimulation of the subthalamic nucleus. The patients were treated for more than 1 year (up to 36 months). At the last visit, the Unified Parkinson Disease Rating Scale (UPDRS) motor score without medication improved by 50.2% (p < 0.001) and the UPDRS activities of daily living score improved by 68.4% (p < 0.001). The most common long-lasting adverse events were hypophonia and dysarthria; transient events were increased sexuality and mania. The surgical procedure induced transient intraoperative psychosis in seven patients.

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页码：1546 / 1550

页数：5

相关论文

共 11 条

[1] Effect of subthalamic nucleus stimulation on levodopa-induced dyskinesia in Parkinson's disease [J].

Fraix, V ;

Pollak, P ;

Van Blercom, N ;

Xie, J ;

Krack, P ;

Koudsie, A ;

Benabid, AL .

NEUROLOGY, 2000, 55 (12) :1921-1923

[2]

Hariz MI, 2001, MOVEMENT DISORD, V16, P166, DOI 10.1002/1531-8257(200101)16:1<166::AID-MDS1031>3.0.CO

[3]

2-S

[4] Chronic stimulation of subthalamic nucleus improves levodopa-induced dyskinesias in Parkinson's disease [J].

Krack, P ;

Limousin, P ;

Benabid, AL ;

Pollak, P .

LANCET, 1997, 350 (9092) :1676-1676

[5] Treatment of tremor in Parkinson's disease by subthalamic nucleus stimulation [J].

Krack, P ;

Benazzouz, A ;

Pollak, P ;

Limousin, P ;

Piallat, B ;

Hoffmann, D ;

Xie, J ;

Benabid, AL .

MOVEMENT DISORDERS, 1998, 13 (06) :907-914

[6] Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson's disease [J].

Kumar, R ;

Lozano, AM ;

Kim, YJ ;

Hutchison, WD ;

Sime, E ;

Halket, E ;

Lang, AE .

NEUROLOGY, 1998, 51 (03) :850-855

[7] CORE ASSESSMENT PROGRAM FOR INTRACEREBRAL TRANSPLANTATIONS (CAPIT) [J].

LANGSTON, JW ;

WIDNER, H ;

GOETZ, CG ;

BROOKS, D ;

FAHN, S ;

FREEMAN, T ;

WATTS, R .

MOVEMENT DISORDERS, 1992, 7 (01) :2-13

[8] Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease [J].

Limousin, P ;

Krack, P ;

Pollak, P ;

Benazzouz, A ;

Ardouin, C ;

Hoffmann, D ;

Benabid, AL .

NEW ENGLAND JOURNAL OF MEDICINE, 1998, 339 (16) :1105-1111

[9] Chronic subthalamic nucleus stimulation reduces medication requirements in Parkinson's disease [J].

Moro, E ;

Scerrati, M ;

Romito, LMA ;

Roselli, R ;

Tonali, P ;

Albanese, A .

NEUROLOGY, 1999, 53 (01) :85-90

[10]

VALLDEORIOLA F, 2002, IN PRESS MOV DISORD