Lewis acid induced synthetic equivalents of imines and iminum ion, part 12 - Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate

被引：16

作者：

Ha, HJ ^{[1
]}

Ahn, YG

Lee, GS

机构：

[1] Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, Kyunggi Do, South Korea

[2] Hanmi Pharmaceut Co Ltd, Cent Res Inst, Seongnam 463400, Kyunggi Do, South Korea

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 12期

关键词：

D O I：

10.1016/S0957-4166(99)00249-9

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric synthesis of 3-amino-2-hydroxy-4-phenylbutanoate, a key component of the natural product bestatin and HIV protease inhibitors of KNI-272 and R-87366, has been achieved from the stereoselective aldimine coupling reaction between 3-phenyl-2-aminopropanenitrile and (Z)-alpha-methoxy trimethylsilyl ketene acetal in the presence of Lewis acids. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2327 / 2336

页数：10

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