A cross-sectional study of the forearm bone density of long-term users of levonorgestrel-releasing intrauterine system

被引：26

作者：

Bahamondes, L ^{[1
]}

Espejo-Arce, X ^{[1
]}

Hidalgo, MM ^{[1
]}

Hidalgo-Regina, C ^{[1
]}

Teatin-Juliato, C ^{[1
]}

Petta, CA ^{[1
]}

机构：

[1] Univ Estadual Campinas, Sch Med, Dept Obstet & Gynaecol, Human Reprod Unit, Campinas, SP, Brazil

来源：

HUMAN REPRODUCTION | 2006年 / 21卷 / 05期

基金：

巴西圣保罗研究基金会;

关键词：

bone mineral density; contraception; levonorgestrel-releasing intrauterine system; Mirena (R);

D O I：

10.1093/humrep/dei457

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

BACKGROUND: There are concerns about the effect of hormonal contraceptives on bone mineral density (BMD), but there is currently no information available on the effect of the levonorgestrel-releasing intrauterine system (LNG-IUS) on BMD. The objective of this study was to compare the BMD of LNG-IUS users with that of controls using the TCu380A intrauterine device (IUD). MATERIALS AND METHODS: A cross-sectional study paired 53 women, aged 25-51 years, who had been using the LNG-IUS for 7 years, with 53 IUD users, according to age (+/- 1 year) and body mass index (BMI; kg/m(2)) (+/- 1). BMD was evaluated at the midshaft of the ulna and the distal radius of the nondominant forearm using double X-ray absorptiometry. RESULTS: Mean age of women was 34 years. BMI was slightly over 25 in both groups. Estradiol was normal. Mean BMD was 0.469 +/- 0.008 and 0.467 +/- 0.009 and 0.409 +/- 0.009 and 0.411 +/- 0.009 at the midshaft of the ulna and distal radius in LNG-IUS and IUD users, respectively, without significant differences. CONCLUSIONS: Women aged 25-51 years, using the LNG-IUS for 7 years, had a mean BMD similar to that of the control group of TCu380A IUD users.

引用

页码：1316 / 1319

页数：4

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