Retinoid differentiation therapy in promyelocytic leukemia

被引：120

作者：

Chomienne, C ^{[1
]}

Fenaux, P ^{[1
]}

Degos, L ^{[1
]}

机构：

[1] CHU LILLE, F-59037 LILLE, FRANCE

来源：

FASEB JOURNAL | 1996年 / 10卷 / 09期

关键词：

APL; acute myeloid leukemia; RAR; ATRA therapy; RA efficacy;

D O I：

10.1096/fasebj.10.9.8801163

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Acute promyelocytic leukemia (APL) is a specific type of acute myeloid leukemia characterized by the morphology of the blast cells, a specific t(15;17) translocation, and risks of definite coagulopathy, Recently this leukemia was further characterized by an exquisite sensitivity to all-trans retinoic acid's differentiation effect and the production of a fusion gene altering the gene of RAR alpha and a novel gene PML. In vivo differentiation therapy with retinoids in APL patients follows strict guidelines related both to the APL cell and the biodisposal of all-trans retinoic acid.

引用

页码：1025 / 1030

页数：6

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