Recognition of synthetic oligopeptides from nonstructural proteins NS1 and NS3 of dengue-4 virus by sera from dengue virus-infected children

被引：26

作者：

Garcia, G ^{[1
]}

Vaughn, DW ^{[1
]}

DelAngel, RM ^{[1
]}

机构：

[1] ARMED FORCES RES INST MED SCI, DEPT VIROL, BANGKOK 10400, THAILAND

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1997年 / 56卷 / 04期

关键词：

RECOMBINANT VACCINIA VIRUS; MONOCLONAL-ANTIBODIES; GLYCOPROTEIN NS1; MICE; PATHOGENESIS; IMMUNIZATION; ENCEPHALITIS; PROTECTION; SITES;

D O I：

10.4269/ajtmh.1997.56.466

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The nonstructural proteins NS1 and NS3 from dengue virus are involved in the immune response during natural infection in humans. To analyze the immunogeneity of some epitopes present in NS1 and NS3 proteins from dengue virus type-4, six oligopeptides were synthesized; five from NS1 (NS1.1, NS1.2, NS1.3, NS1.4, and NS1.5) and one from NS3 (NS3.1). Peptides NS1.1, NS1.2, NS1.3, NS1.5, and NS3.1 were recognized by sera from dengue virus-infected children, suggesting that they represent exposed epitopes during natural dengue virus infection.

引用

页码：466 / 470

页数：5

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