Controversies on the role of Th17 in cancer: a TGF-β-dependent immunosuppressive activity?

被引：92

作者：

Martin, Francois ^{[1
,2
]}

Apetoh, Lionel ^{[1
,2
,3
]}

Ghiringhelli, Francois ^{[1
,2
,3
]}

机构：

[1] INSERM, U866, Dijon, France

[2] Univ Bourgogne, Fac Med, Dijon, France

[3] Ctr Georges Francois Leclerc, Dijon, France

来源：

TRENDS IN MOLECULAR MEDICINE | 2012年 / 18卷 / 12期

关键词：

Th17; tumor immunity; immunosuppression; angiogenesis; plasticity; TGF-beta; ectonucleotidases; adenosine; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; GROWTH-FACTOR-BETA; T(H)17 CELLS; PROMOTES ANGIOGENESIS; DIFFERENT SUBSETS; PERIPHERAL-BLOOD; TRANSIENT NATURE; CYTOKINE; IL-17;

D O I：

10.1016/j.molmed.2012.09.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The immune system has important roles in limiting the spread of cancer and shaping the tumor microenvironment. Although the contributions of T helper 17 (Th17) cells (a subtype of CD4(+) T lymphocytes) to autoimmunity and allergy response are well known, their roles in cancer remain ambiguous. Despite adoptive transfer studies indicating that mouse Th17 cells support anticancer immunity, the Th17 cells that naturally infiltrate experimental tumors appear to have a tumor-promoting effect. These contradictory properties can be related to the high degree of plasticity inherent in Th17 cells and their capacity to differentiate into tumoricidal Th1-like cells. Mouse Th17 cells induced by transforming growth factor-beta (TGF-beta) express CD39 and CD73 ectonucleotidases on their surfaces, which leads to adenosine release and suppression of T cell immunity. Here, we discuss how TGF-beta acts as a molecular switch controlling the immunoregulatory properties of Th17 cells.

引用

页码：742 / 749

页数：8

共 85 条

[1]

Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells [J].