The Role of the ω-3 Fatty Acid DHA in the Human Life Cycle

被引：54

作者：

Carlson, Sarah J. ^{[1
,2
]}

Fallon, Erica M. ^{[1
,2
]}

Kalish, Brian T. ^{[1
,2
]}

Gura, Kathleen M. ^{[3
]}

Puder, Mark ^{[1
,2
]}

机构：

[1] Boston Childrens Hosp, Dept Surg, Boston, MA 02115 USA

[2] Boston Childrens Hosp, Vasc Biol Program, Boston, MA 02115 USA

[3] Boston Childrens Hosp, Dept Pharm, Boston, MA 02115 USA

来源：

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION | 2013年 / 37卷 / 01期

关键词：

neonates; lipids; fatty acids; pediatrics; pregnancy; geriatrics; POLYUNSATURATED FATTY-ACIDS; RED-BLOOD-CELL; DOCOSAHEXAENOIC ACID; VISUAL-ACUITY; COGNITIVE PERFORMANCE; GESTATIONAL-AGE; GENE-TRANSFER; RESOLVIN E1; IN-VIVO; N-3;

D O I：

10.1177/0148607112467821

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Dietary consumption of the essential fatty acids linoleic acid (LA; omega-6) and alpha-linolenic acid (ALA; omega-3) is necessary for human growth and development. In the past 150 years, the average Western diet has changed dramatically such that humans today consume a much higher proportion of omega-6 fatty acids relative to omega-3 fatty acids than ever before. The importance of omega-3 fatty acids in human development has been well established in fetal and neonatal development, with brain and retinal tissues highly dependent on omega-3 fatty acids, specifically docosahexaenoic acid (DHA) for membrane fluidity and signal transduction. In childhood, omega-3s have been shown to contribute to ongoing cognitive development and may be involved in metabolic programming of bone turnover and adipogenesis. omega-3s may also play important roles in adult neurophysiology and disease prevention. (JPEN J Parenter Enteral Nutr. 2013;37:15-22)

引用

页码：15 / 22

页数：8

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