Controlled ovarian hyperstimulation adversely affects implantation following in vitro fertilization-embryo transfer

被引:89
作者
Check, JH [1 ]
Choe, JK [1 ]
Katsoff, D [1 ]
Summers-Chase, D [1 ]
Wilson, C [1 ]
机构
[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Cooper Hosp, Med Ctr,Dept Obstet & Gynecol,Div Reprod Endocrin, Camden, NJ 08103 USA
关键词
frozen embryo transfer; implantation; recipient; shared oocytes;
D O I
10.1023/A:1020565408018
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Purpose: Our purpose was to determine if controlled ovarian hyperstimulation adversely affects implantation. Methods: A retrospective comparison of pregnancy rates (PRs) and implantation rates was made between oocyte recipients versus their donors, who shared half of the retrieved oocytes, and regular patients undergoing in vitro fertilization-embryo transfer (IVF-ET) who were not sharing eggs. Results: Higher implantation rates (39.0 vs 22.5%; P < 0.05) were found in recipients compared to donors in the stimulated cycle. However; no differences were seen in PRs or implantation rates in frozen ET cycles. The data for standard IVF patients were almost-identical to those for donors. Conclusions: Superior implantation rates and PRs in oocyte recipients versus donors were nor related to better oocyte quality for recipients because of egg sharing or to a better uterine environment because of similar results with frozen ET in all three groups. An adverse effect of the hyperstimulation regimen best explains the difference.
引用
收藏
页码:416 / 420
页数:5
相关论文
共 22 条
[1]   ARTIFICIAL HORMONAL REPLACEMENT CYCLES HAVE NO ADVANTAGE OVER HYPERSTIMULATED CYCLES IN A GAMETE INTRAFALLOPIAN TRANSFER OOCYTE DONATION PROGRAM [J].
ALKHATIB, RA ;
FAKIH, H .
FERTILITY AND STERILITY, 1995, 63 (06) :1255-1259
[2]   LOW IMPLANTATION RATE AFTER IN-VITRO FERTILIZATION IN PATIENTS WITH HYDROSALPINGES DIAGNOSED BY ULTRASONOGRAPHY [J].
ANDERSEN, AN ;
YUE, Z ;
MENG, FJ ;
PETERSEN, K .
HUMAN REPRODUCTION, 1994, 9 (10) :1935-1938
[3]  
Andersen AN, 1996, HUM REPROD, V11, P2081
[4]  
AUBRIOT FX, 1995, CONTRACEPT FERTIL S, V23, P670
[5]  
BENNUN I, 1989, FERTIL STERIL, V52, P683
[6]   The impact of hydrosalpinx on successful pregnancy in tubal factor infertility treated by in vitro fertilization [J].
Blazar, AS ;
Hogan, JW ;
Seifer, DB ;
Frishman, GN ;
Wheeler, CA ;
Haning, RV .
FERTILITY AND STERILITY, 1997, 67 (03) :517-520
[7]   Evaluation of the mechanism for higher pregnancy rates in donor oocyte recipients by comparison of fresh with frozen embryo transfer pregnancy rates in a shared oocyte programme [J].
Check, JH ;
OShaughnessy, A ;
Lurie, D ;
Fisher, C ;
Adelson, HG .
HUMAN REPRODUCTION, 1995, 10 (11) :3022-3027
[8]   ADVERSE EFFECT OF A HOMOGENEOUS HYPERECHOGENIC ENDOMETRIAL SONOGRAPHIC PATTERN, DESPITE ADEQUATE ENDOMETRIAL THICKNESS ON PREGNANCY RATES FOLLOWING IN-VITRO FERTILIZATION [J].
CHECK, JH ;
LURIE, D ;
DIETTERICH, C ;
CALLAN, C ;
BAKER, A .
HUMAN REPRODUCTION, 1993, 8 (08) :1293-1296
[9]   Does previous salpingectomy improve implantation and pregnancy rates in patients with severe tubal factor infertility who are undergoing in vitro fertilization?: A pilot prospective randomized study [J].
Déchaud, H ;
Daurès, JP ;
Arnal, F ;
Humeau, C ;
Hédon, B .
FERTILITY AND STERILITY, 1998, 69 (06) :1020-1025
[10]   SYNCHRONIZATION OF DONORS AND RECIPIENTS CYCLES WITH GNRH ANALOGS IN AN OOCYTE DONATION PROGRAM [J].
DEVROEY, P ;
SMITZ, J ;
CAMUS, M ;
WISANTO, A ;
DESCHACHT, J ;
VANWAESBERGHE, L ;
VANSTEIRTEGHEM, AC .
HUMAN REPRODUCTION, 1989, 4 (03) :270-274