Platelet serotonin transporter in coeliac disease

被引：3

作者：

Chiaravalloti, G ^{[1
]}

Marazziti, D ^{[1
]}

Batistini, A ^{[1
]}

Favilli, T ^{[1
]}

Ughi, C ^{[1
]}

Ceccarelli, M ^{[1
]}

Cassano, GB ^{[1
]}

机构：

[1] UNIV PISA,INST PSYCHIAT,I-56100 PISA,ITALY

来源：

ACTA PAEDIATRICA | 1997年 / 86卷 / 07期

关键词：

coeliac disease; serotonin; blood platelets; serotonin transporter; H-3-imipramine binding sites;

D O I：

10.1111/j.1651-2227.1997.tb08570.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

We investigated a peripheral serotonergic marker, i.e. platelet tritiated imipramine (H-3-IMI) binding sites, which are part of the 5-HT transporter complex similar to that present in the brain, in 20 patients affected by coeliac disease (CD), as compared with 20 healthy controls. Platelet membranes and H-3-IMI binding were carried out according to a standardized protocol. The results showed that coeliac patients had significantly lower H-3-IMI binding sites than controls. This finding would suggest the presence of a dysfunction at the level of the 5-HT transporter that might underline the psychic disturbances frequently observed in coeliac patients.

引用

页码：696 / 699

页数：4

共 31 条

[1] [H-3] PAROXETINE BINDING IN HUMAN PLATELETS IN RELATION TO AGE AND SEX [J].