Circulating monocyte chemoattractant protein-1 in heart transplant recipients with cardiac allograft vasculopathy

被引:4
作者
Beaudeux, JL
Dorent, R
Bernard, M
Reagan, M
Foglietti, MJ
Gandjbakhch, I
Cacoub, P
机构
[1] Grp Hosp Pitie Salpetriere, Serv Biochim C, F-75013 Paris, France
[2] Grp Hosp Pitie Salpetriere, Serv Chirurg CardioVasc, F-75013 Paris, France
[3] Grp Hosp Pitie Salpetriere, Serv Med Interne, F-75013 Paris, France
关键词
monocyte chemoattractant protein-1; heart transplantation; cardiac allograft vasculopathy; adhesion molecules; selectins;
D O I
10.1016/S0009-9120(02)00276-X
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Objective: To evaluate serum Monocyte Chemoattractant Protein-1 (MCP-1) as a biologic marker of cardiac allograft vasculopathy (CAV) in heart transplant recipients (HTR). Design and methods: Serum levels of MCP-1 were measured in 49 HTR with and without CAV. Results: HTR exhibited significantly higher serum MCP-1 levels than controls. However, no difference was observed according to the existence of CAV. Conclusion: Serum MCP-1 levels do not constitute a marker of the CAV occurring after heart transplantation. (C) 2002 The Canadian Society of Clinical Chemists. All rights reserved.
引用
收藏
页码:77 / 79
页数:3
相关论文
共 9 条
  • [1] Monocyte chemoattractant protein-1 accelerates atherosclerosis in apolipoprotein E-deficient mice
    Aiello, RJ
    Bourassa, PAK
    Lindsey, S
    Weng, WF
    Natoli, E
    Rollins, BJ
    Milos, PM
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (06) : 1518 - 1525
  • [2] Levels of circulating adhesion molecules in congestive heart failure and after heart transplantation
    Andreassen, AK
    Nordoy, I
    Simonsen, S
    Ueland, T
    Müller, F
    Froland, SS
    Gullestad, L
    Aukrust, P
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 81 (05) : 604 - 608
  • [3] VASCULAR CELL-ADHESION MOLECULE-1 INDUCED ON VASCULAR ENDOTHELIA AND MEDIAL SMOOTH-MUSCLE CELLS IN EXPERIMENTAL CARDIAC ALLOGRAFT VASCULOPATHY
    ARDEHALI, A
    LAKS, H
    DRINKWATER, DC
    ZIV, E
    DRAKE, TA
    [J]. CIRCULATION, 1995, 92 (03) : 450 - 456
  • [4] Gu L, 1999, Chem Immunol, V72, P7, DOI 10.1159/000058723
  • [5] Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    Gu, L
    Okada, Y
    Clinton, SK
    Gerard, C
    Sukhova, GK
    Libby, P
    Rollins, BJ
    [J]. MOLECULAR CELL, 1998, 2 (02) : 275 - 281
  • [6] Possible role of proinflammatory cytokines in heart allograft coronary artery disease
    Gullestad, L
    Simonsen, S
    Ueland, T
    Holm, T
    Aass, H
    Andreassen, AK
    Madsen, S
    Geiran, O
    Froland, SS
    Aukrust, P
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1999, 84 (09) : 999 - 1003
  • [7] Increase in circulating levels of monocyte chemoattractant protein-1 with aging
    Inadera, H
    Egashira, K
    Takemoto, M
    Ouchi, Y
    Matsushima, K
    [J]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 1999, 19 (10) : 1179 - 1182
  • [8] Radio S, 1996, TRANSPLANT P, V28, P496
  • [9] Early and late chemokine production correlates with cellular recruitment in cardiac allograft vasculopathy
    Yun, JJ
    Fischbein, MP
    Laks, H
    Fishbein, MC
    Espejo, ML
    Ebrahimi, K
    Irie, Y
    Berliner, J
    Ardehali, A
    [J]. TRANSPLANTATION, 2000, 69 (12) : 2515 - 2524