Cross-linked collagen C- and N-telopeptides for an early diagnosis of bone metastasis from breast cancer

被引：9

作者：

Kiuchi, K ^{[1
]}

Ishikawa, T ^{[1
]}

Hamaguchi, Y ^{[1
]}

Momiyama, N ^{[1
]}

Hasegawa, S ^{[1
]}

Ishiyama, A ^{[1
]}

Kono, T ^{[1
]}

Doi, T ^{[1
]}

Chishima, T ^{[1
]}

Shimada, H ^{[1
]}

机构：

[1] Yokohama City Univ, Dept Surg 2, Kanazawa Ku, Yokohama, Kanagawa 2360004, Japan

来源：

ONCOLOGY REPORTS | 2002年 / 9卷 / 03期

关键词：

breast cancer; bone metastasis; ICTP; NTx;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Bone resorption markers have become available for the diagnosis of bone metastasis. We evaluated crosslinked collagen C-and N-telopeptides (ICTP and NTx) in diagnosing bone metastasis from breast cancer. For a threshold of 4.5 ng/ml of ICTP and 55.0 pmol BCE/mumol of NTx, bone metastasis could be predicted with an accuracy of 84% and 63%, respectively. All the patients who had metastatic lesions, but showed lower than 4.5 ng/ml of ICTP, had a solitary lesion of bone metastasis. Although ICTP is not sensitive enough to detect an early stage of bone metastasis, it is a better biochemical marker than NTx for detecting bone metastasis from breast cancer.

引用

页码：595 / 598

页数：4

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