HIV-infected long-term nonprogressors: epidemiology, mechanisms of delayed progression, and clinical and research implications

被引:34
作者
Buchbinder, S
Vittinghoff, E
机构
[1] San Francisco Dept Publ Hlth, HIV Res Sect, San Francisco, CA 94102 USA
[2] Univ Calif San Francisco, Dept Epidemiol & Biostat, San Francisco, CA 94143 USA
关键词
HIV; nonprogressor; progression; survival; cofactors;
D O I
10.1016/S1286-4579(99)00204-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Long-term nonprogressors (LTNPs) should be defined as untreated HIV-infected persons without AIDS and with high CD4(+) counts and low plasma viral loads 10 or more years after infection. Although no demographic or behavioral variables distinguish LTNPs, studies should be expanded to include geographically and ethnically diverse groups. Underlying mechanisms for delayed progression appear to include strong CD8(+) cytotoxic T-lymphocyte and noncytolytic suppressive activity, host genetic factors including chemokine receptor polymorphisms, and infection with attenuated viral strains. (C) 1999 Editions scientifiques et medicales Elsevier SAS.
引用
收藏
页码:1113 / 1120
页数:8
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