Simultaneous determination of metronidazole benzoate, methylparaben, and propylparaben by high-performance liquid chromatography

被引：19

作者：

Ali, MS ^{[1
]}

Chaudhary, RS ^{[1
]}

Takieddin, MA ^{[1
]}

机构：

[1] Tabuk Pharmaceut Mfg Co, Tabuk, Saudi Arabia

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1999年 / 25卷 / 10期

关键词：

D O I：

10.1081/DDC-100102281

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The simultaneous determination of metronidazole benzoate (MB), methylparaben (MP), and propylparaben (PP) in an oral suspension formulation was developed using high-performance liquid chromatography (HPLC). The method was developed using a Novapak C-18 (3.9 x 150 mm, 4 mu m) column methanol-water (50:50 v/v) as the mobile phase and an ultraviolet (UV) detector at 254 nm. The peak area response versus concentration was linear in a concentration range from 40 to 400 mu g/ml of MB, 0.8 to 8.0 mu g/ml of MP, and 0.2 to 2.0 mu g of PP. The correlation coefficients were 0.9997 for MB, 0.9987 for MP, and 0.9983 for PP, with relative standard errors of 1.12%, 1.28, and 1.67%, respectively.

引用

页码：1143 / 1147

页数：5

共 15 条

[1] High performance liquid chromatographic determination of phenoxetol, methyl paraben, ethyl paraben, n-propyl paraben, iso-butyl paraben, n-butyl paraben and croconazole center dot HCl [J].