Lack of NMDA-AMPA interaction in antidepressant-like effect of CGP 37849, an antagonist of NMDA receptor, in the forced swim test

被引：20

作者：

Dybala, Malgorzata ^{[1
]}

Siwek, Agata ^{[1
]}

Poleszak, Ewa ^{[3
]}

Pilc, Andrzej ^{[2
]}

Nowak, Gabriel ^{[1
,2
]}

机构：

[1] Jagiellonian Univ, Coll Med, Dept Cytobiol & Histochem, Lab Pharmacobiol, PL-30688 Krakow, Poland

[2] Polish Acad Sci, Inst Pharmacol, Dept Neurobiol, PL-31343 Krakow, Poland

[3] Skubiszewski Med Univ Lublin, Dept Pharmacol & Pharmacodynam, PL-20081 Lublin, Poland

来源：

JOURNAL OF NEURAL TRANSMISSION | 2008年 / 115卷 / 11期

关键词：

NMDA antagonist; AMPA antagonist; FST;

D O I：

10.1007/s00702-008-0128-2

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The NMDA receptor antagonist, CGP 37849-induced reduction in immobility time in the forced swim test in mice was not antagonized by pre-treatment with the AMPA receptor antagonist NBQX. This is the first demonstration of the antidepressant effect of the NMDA antagonist not being dependent on the AMPA transmission.

引用

页码：1519 / 1520

页数：2

共 11 条

[1] New approaches to antidepressant drug discovery: beyond monoamines [J].

Berton, O ;

Nestler, EJ .

NATURE REVIEWS NEUROSCIENCE, 2006, 7 (02) :137-151

[2]

Bleakman D., 2007, CNS & Neurological Disorders-Drug Targets, V6, P117, DOI 10.2174/187152707780363258

[3] CGP-37849 AND CGP-39551 - NOVEL AND POTENT COMPETITIVE N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS WITH ORAL ACTIVITY [J].

FAGG, GE ;

OLPE, HR ;

POZZA, MF ;

BAUD, J ;

STEINMANN, M ;

SCHMUTZ, M ;

PORTET, C ;

BAUMANN, P ;

THEDINGA, K ;

BITTIGER, H ;

ALLGEIER, H ;

HECKENDORN, R ;

ANGST, C ;

BRUNDISH, D ;

DINGWALL, JG .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (04) :791-797

[4] Cellular mechanisms underlying the antidepressant effects of ketamine:: Role of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors [J].

Maeng, Sungho ;

Zarate, Carlos A., Jr. ;

Du, Jing ;

Schloesser, Robert J. ;

McCammon, Joseph ;

Chen, Guang ;

Manji, Husseini K. .

BIOLOGICAL PSYCHIATRY, 2008, 63 (04) :349-352

[5]

Poleszak E, 2007, PHARMACOL REP, V59, P595

[6] Lack of persistent effects of ketamine in rodent models of depression [J].

Popik, Piotr ;

Kos, Tomasz ;

Sowa-Kucma, Magdalena ;

Nowak, Gabriel .

PSYCHOPHARMACOLOGY, 2008, 198 (03) :421-430

[7]

PORSOLT RD, 1977, ARCH INT PHARMACOD T, V229, P327

[8] Current perspectives on the development of non-biogenic amine-based antidepressants [J].

Skolnick, P ;

Legutko, B ;

Li, X ;

Bymaster, FP .

PHARMACOLOGICAL RESEARCH, 2001, 43 (05) :411-422

[9] Adaptation of N-methyl-D-aspartate (NMDA) receptors following antidepressant treatment: Implications for the pharmacotherapy of depression [J].

Skolnick, P ;

Layer, RT ;

Popik, P ;

Nowak, G ;

Paul, IA ;

Trullas, R .

PHARMACOPSYCHIATRY, 1996, 29 (01) :23-26

[10] Commentary - AMPA receptors: A target for novel antidepressants? [J].

Skolnick, Phil .

BIOLOGICAL PSYCHIATRY, 2008, 63 (04) :347-348

← 1 2 →