Increased CSF levels of prostaglandin E2 in variant Creutzfeldt-Jakob disease

被引：38

作者：

Minghetti, L

Cardone, F

Greco, A

Puopolo, M

Levi, G

Green, AJE

Knight, R

Pocchiari, M

机构：

[1] Ist Super Sanita, Virol Lab, I-00161 Rome, Italy

[2] Ist Super Sanita, Lab Pathophysiol, I-00161 Rome, Italy

[3] Western Gen Hosp, Natl CJD Surveillance Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

NEUROLOGY | 2002年 / 58卷 / 01期

关键词：

D O I：

10.1212/WNL.58.1.127

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The concentration of the cyclooxygenase product prostaglandin E, was sixfold higher in CSF samples from 18 cases of variant Creutzfeldt-Jakob disease (CJD) than in a group of eight subjects with other noninflammatory neurologic diseases, and comparable to those found in a group of six patients affected by diseases with a known inflammatory component. This finding suggests that cyclooxygenase activity may have a role in variant CJD pathogenesis, as previously reported in sporadic CJD.

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页码：127 / 129

页数：3

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