Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

被引：12

作者：

Antonica, Francesco ^{[1
,3
]}

Orietti, Lorenzo Carlo ^{[1
]}

Mort, Richard Lester ^{[2
]}

Zernicka-Goetz, Magdalena ^{[1
]}

机构：

[1] Univ Cambridge, Dept Physiol Dev & Neurosci, Mammalian Embryo & Stem CeIl Grp, Downing St, Cambridge CB2 3DY, England

[2] Univ Lancaster, Fac Hlth & Med, Div Biomed & Life Sci, Furness Bldg, Lancaster LA1 4YG, England

[3] Univ Trento, Dept Cellular Computat & Integrat Biol CIBIO, Armenise Harvard Lab Brain Disorders & Canc, Trento, Italy

来源：

DEVELOPMENTAL BIOLOGY | 2019年 / 450卷 / 02期

基金：

欧洲研究理事会; 英国惠康基金;

关键词：

4D live imaging; Mouse embryo; Post-implantation morphogenesis; Visceral endoderm; PRIMITIVE ENDODERM; MOUSE; AXIS; EPIBLAST; ESTABLISHMENT; MORPHOLOGY; INHIBITOR; REPORTER; FGFR1; CYCLE;

D O I：

10.1016/j.ydbio.2019.03.016

中图分类号：

Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程];

摘要：

Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.

引用

收藏

页码：132 / 140

页数：9

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