COMT Val158Met moderation of cannabis-induced psychosis: a momentary assessment study of 'switching on' hallucinations in the flow of daily life

被引：88

作者：

Henquet, C. ^{[1
,2
]}

Rosa, A. ^{[3
]}

Delespaul, P. ^{[1
]}

Papiol, S. ^{[3
]}

Fananas, L. ^{[3
]}

van Os, J. ^{[1
,4
]}

Myin-Germeys, I. ^{[1
,5
]}

机构：

[1] Maastricht Univ, Med Ctr, S Limburg Mental Hlth Res & Teaching Network, Dept Psychiat & Neuropsychol,EURON, NL-6200 MD Maastricht, Netherlands

[2] Mondriaan Zorggroep, Div Addict Care, S Limburg, Netherlands

[3] Univ Barcelona, Fac Biol, Barcelona, Spain

[4] Kings Coll London, Inst Psychiat, NIHR Biomed Res Ctr, London WC2R 2LS, England

[5] Univ Manchester, Sch Psychol Sci, Manchester, Lancs, England

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 2009年 / 119卷 / 02期

基金：

英国医学研究理事会;

关键词：

Cannabis; psychotic disorders; Catechol-o-methyltransferase gene; FUNCTIONAL POLYMORPHISM; SCHIZOPHRENIA; INDIVIDUALS; ASSOCIATION; EXPERIENCES; ENVIRONMENT; REACTIVITY; STRESS; ONSET; MODEL;

D O I：

10.1111/j.1600-0447.2008.01265.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

A functional polymorphism in the catechol-o-methyltransferase gene (COMT Val(158)Met) may moderate the psychosis-inducing effects of cannabis. In order to extend this finding to dynamic effects in the flow of daily life, a momentary assessment study of psychotic symptoms in response to cannabis use was conducted. The experience sampling technique was used to collect data on cannabis use and occurrence of symptoms in daily life in patients with a psychotic disorder (n = 31) and healthy controls (n = 25). Carriers of the COMT Val(158)Met Val allele, but not subjects with the Met/Met genotype, showed an increase in hallucinations after cannabis exposure, conditional on prior evidence of psychometric psychosis liability. The findings confirm that in people with psychometric evidence of psychosis liability, COMT Val(158)Met genotype moderates the association between cannabis and psychotic phenomena in the flow of daily life.

引用

页码：156 / 160

页数：5

共 23 条

[1] THE SELF, ATTRIBUTIONAL PROCESSES AND ABNORMAL BELIEFS - TOWARDS A MODEL OF PERSECUTORY DELUSIONS [J].

BENTALL, RP ;

KINDERMAN, P ;

KANEY, S .

BEHAVIOUR RESEARCH AND THERAPY, 1994, 32 (03) :331-341

[2] The catechol-O-methyltransferase polymorphism:: Relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes [J].

Bilder, RM ;

Volavka, J ;

Lachman, HM ;

Grace, AA .

NEUROPSYCHOPHARMACOLOGY, 2004, 29 (11) :1943-1961

[3] Moderation of the effect of adolescent-onset cannabis use on adult psychosis by a functional polymorphism in the catechol-O-methyltransferase gene: Longitudinal evidence of a gene X environment interaction [J].

Caspi, A ;

Moffitt, TE ;

Cannon, M ;

McClay, J ;

Murray, R ;

Harrington, H ;

Taylor, A ;

Arseneault, L ;

Williams, B ;

Braithwaite, A ;

Poulton, R ;

Craig, IW .

BIOLOGICAL PSYCHIATRY, 2005, 57 (10) :1117-1127

[4]

CLAYTON D, 1993, STAT MODELS EPIDEMIO, P101

[5]

Daniels JK, 1996, AM J PSYCHIAT, V153, P268

[6]

Delespaul P.A.E.G., 1995, ASSESSING SCHIZOPHRE

[7]

Grace AA, 2000, ADDICTION, V95, pS119

[8] The incidence and outcome of subclinical psychotic experiences in the general population [J].

Hanssen, M ;

Bak, M ;

Bijl, R ;

Vollebergh, W ;

van Os, J .

BRITISH JOURNAL OF CLINICAL PSYCHOLOGY, 2005, 44 :181-191

[9] The environment and schizophrenia: The role of cannabis use [J].

Henquet, C ;

Murray, R ;

Linszen, D ;

van Os, J .

SCHIZOPHRENIA BULLETIN, 2005, 31 (03) :608-612

[10] An experimental study of catechol-O-methyltransferase Val158Met moderation of Δ-9-tetrahydrocannabinol-induced effects on psychosis and cognition [J].

Henquet, Cecile ;

Rosa, Araceli ;

Krabbendam, Lydia ;

Papiol, Sergi ;

Fananas, Lourdes ;

Drukker, Marjan ;

Ramaekers, Johannes G. ;

van Os, Jim .

NEUROPSYCHOPHARMACOLOGY, 2006, 31 (12) :2748-2757

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