The influence of combretastatin A-4 and vinblastine on interstitial fluid pressure in BT4An rat gliomas

被引：16

作者：

Eikesdal, HP ^{[1
]}

Landuyt, W

Dahl, O

机构：

[1] Univ Bergen, Dept Oncol, Haukeland Univ Hosp, N-5021 Bergen, Norway

[2] Katholieke Univ Leuven, Univ Hosp Gasthuisberg, Dept Expt Radiobiol Radiotherapy, B-3000 Louvain, Belgium

来源：

CANCER LETTERS | 2002年 / 178卷 / 02期

关键词：

combretastatin A-4 disodium phosphate vinblastine; interstitial fluid pressure; tumor volume; anti-vascular therapy; drug distribution;

D O I：

10.1016/S0304-3835(01)00835-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The influence of combretastatin A-4 disodium phosphate (CA-4, 50 mg/kg intraperitoneally (i.p.)) and vinblastine (2 mg/kg i.p.) on interstitial fluid pressure (IFP) was assessed in BT(4)An rat gliomas implanted subcutaneously in the neck. Furthermore the growth inhibitory effect of vinblastine and the distribution of fluorescence-conjugated vinblastine (BODIPY-vinblastine) were investigated, Tumors at different volumes were compared. Whereas CA-4 had no major influence on IFP, independent of tumor size, vinblastine increased the lFP in neoplasms above 8 cm(3) (P = 0.03). Vinblastine yielded a significant tumor response only in tumors below 2.1 cm(3) (P = 0.03), The distribution of BODIPY-vinblastine was heterogeneous and comparable despite tumor volume differences. We conclude that the influence of vinblastine on iFP is more pronounced than that of CA-4 in BT(4)An neck tumors, and that vinblastine may reduce subsequent drug delivery to solid tumors by increasing the IFP. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：209 / 217

页数：9

共 49 条

[1] INHIBITION OF GROWTH OF COLON-38 ADENOCARCINOMA BY VINBLASTINE AND COLCHICINE - EVIDENCE FOR A VASCULAR MECHANISM [J].

BAGULEY, BC ;

HOLDAWAY, KM ;

THOMSEN, LL ;

ZHUANG, L ;

ZWI, LJ .

EUROPEAN JOURNAL OF CANCER, 1991, 27 (04) :482-487

[2]

BAXTER LT, 1991, TUMOR BLOOD SUPPLY M, V20, P155

[3]

Beauregard DA, 2001, CANCER RES, V61, P6811

[4] Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal [J].

Benjamin, LE ;

Golijanin, D ;

Itin, A ;

Pode, D ;

Keshet, E .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (02) :159-165

[5]

BOUCHER Y, 1990, CANCER RES, V50, P4478

[6] Interstitial fluid pressure in intracranial tumours in patients and in rodents [J].

Boucher, Y ;

Salehi, H ;

Witwer, B ;

Harsh, GR ;

Jain, RK .

BRITISH JOURNAL OF CANCER, 1997, 75 (06) :829-836

[7]

BOUCHER Y, 1992, CANCER RES, V52, P5110

[8]

CURTI BD, 1993, CANCER RES, V53, P2204

[9]

Dark GG, 1997, CANCER RES, V57, P1829

[10] PHARMACOLOGY OF DIMETHYL SULFOXIDE [J].

DAVID, NA .

ANNUAL REVIEW OF PHARMACOLOGY, 1972, 12 :353-+

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