Significance of fluorescence cystoscopy for diagnosis of superficial bladder cancer after intravesical instillation of delta aminolevulinic acid

被引：13

作者：

Ehsan, A ^{[1
]}

Sommer, F ^{[1
]}

Haupt, G ^{[1
]}

Engelmann, U ^{[1
]}

机构：

[1] Univ Cologne, Dept Urol, D-5000 Cologne 41, Germany

来源：

UROLOGIA INTERNATIONALIS | 2001年 / 67卷 / 04期

关键词：

bladder; cancer; photodynamic diagnosis; delta aminolevulinic acid; fluorescence;

D O I：

10.1159/000051007

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: Most lesions of superficial bladder cancer may be easily missed during conventional white light cystoscopy. The aim of this work was to evaluate the efficiency of endoscopic fluorescence diagnosis of superficial malignant bladder tumours following intravesical instillation of delta-aminoleviulenic acid. Patients and Methods: 30 patients of suspected or previously diagnosed bladder cancer were subject of evaluation. All patients received 50 ml of a 3% delta-ALA solution intravesically, 2-3 h prior to diagnostic cystoscopy. Fluorescence excitation intraoperatively was achieved by a violet-blue light from a xenon light source. Results: A clear strong red fluorescence colour was observed emitting from all malignant vesical lesions. A diagnostic sensitivity of 98% and specificity of 65% has been determined for this novel diagnostic modality. Conclusion: Fluorescence cystoscopy using delta-ALA is a reliable procedure that can be offered to all patients with suspected bladder cancer lesions. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：298 / 304

页数：7

共 26 条

[1] NON-INVASIVE PAPILLARY CARCINOMA OF BLADDER ASSOCIATED WITH CARCINOMA INSITU [J].