Retinal angiogenesis in development and disease

被引：567

作者：

Gariano, RF

Gardner, TW

机构：

[1] Stanford Univ, Sch Med, Dept Ophthalmol, Palo Alto, CA 94305 USA

[2] Penn State Coll Med, Dept Ophthalmol, Hershey, PA 17033 USA

[3] Penn State Coll Med, Dept Cellular & Mol Physiol, Hershey, PA 17033 USA

来源：

NATURE | 2005年 / 438卷 / 7070期

关键词：

D O I：

10.1038/nature04482

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The retina has long been regarded as 'an approachable part of the brain' for investigating neurosensory processes. Cell biologists are now capitalizing on the accessibility of the retina to investigate important aspects of developmental angiogenesis, including how it relates to neuronal and glial development, morphogenesis, oxygen sensing and progenitor cells. Pathological angiogenesis also occurs in the retina and is a major feature of leading blinding diseases, particularly diabetic retinopathy. The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases.

引用

收藏

页码：960 / 966

页数：7

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