Antidepressant-like effect of icariin and its possible mechanism in mice

被引：123

作者：

Pan, Y ^{[1
]}

Kong, LD ^{[1
]}

Xia, X ^{[1
]}

Zhang, WY ^{[1
]}

Xia, ZH ^{[1
]}

Jiang, FX ^{[1
]}

机构：

[1] Nanjing Univ, Inst Funct Biomol, Immunobiol Lab, State Key Lab Pharmaceut Biotechnol, Nanjing 210093, Peoples R China

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2005年 / 82卷 / 04期

基金：

中国国家自然科学基金;

关键词：

icariin; forced swimming test; tail suspension test; monoamine neurotransmitters; monoamine oxidase; corticotropin-releasing factor;

D O I：

10.1016/j.pbb.2005.11.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

The behavioral, neurochemical and neuroendocrine effects of icariin isolated from Epimedium brevicornum were investigated in behavioral despair models of KunMing strain of male mice. Icariin was found to significantly shorten immobility time in the forced swimming test (FST) after orally administration for 21 consecutive days. Icarrin also produced a marked reduction in immobility time in the tail suspension test (TST) when administered for at least 7 consecutive days. The preferable antidepressant action by icariin was obtained at 17.5 and 35 mg/kg in the present study. Moreover, it was observed that the stress of FST exposure induced increases in brain monoamine oxidase (MAO) A and B activities, serum corticotropin-releasing factor (CRF) levels, as well as decreases in brain monoamine neurotransmitter levels. Treatment of icariin for 21 consecutive days mainly reversed the above effects in the mouse FST. These results suggested that icarrin possessed potent antidepressant-like properties that were mediated via neurochemical and neuroendocrine systems. (C) 2005 Elsevier Inc. All rights reserved.

引用

页码：686 / 694

页数：9

共 38 条

[1] A SENSITIVE AND RAPID HPLC-ECD METHOD FOR THE SIMULTANEOUS ANALYSIS OF NOREPINEPHRINE, DOPAMINE, SEROTONIN AND THEIR PRIMARY METABOLITES IN BRAIN-TISSUE [J].