There is more to life and death than mitochondria: Bcl-2 proteins at the endoplasmic reticulum

被引：50

作者：

Annis, MG

Yethon, JA

Leber, B

Andrews, DW

机构：

[1] McMaster Univ, Med Ctr, Dept Biochem, Hamilton, ON L8N 3Z5, Canada

[2] McMaster Univ, Med Ctr, Dept Med, Hamilton, ON L8N 3Z5, Canada

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2004年 / 1644卷 / 2-3期

关键词：

Bcl-2; endoplasmic reticulum; calcium; Bap31; Bax;

D O I：

10.1016/j.bbamcr.2003.07.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Proteins of the Bcl-2 family are important regulators of cell fate. The role of these proteins in controlling mitochondrial apoptotic processes has been extensively investigated, although exact molecular mechanisms are incompletely understood. However, mounting evidence indicates that these proteins also function at the endoplasmic reticulurn and other locations within the cell. Both pro- and antiapoptotic Bcl-2 family members can regulate endoplasmic reticulum calcium, cellular pH and endoplasmic reticulum. resident proteins. In this review, we discuss the activities and potential targets of Bcl-2 family members at the endoplasmic reticulum and other cellular locations. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：115 / 123

页数：9

共 75 条

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