Enantioselective total synthesis of eurylene, 14-deacetyl eurylene, and their 11-epimers: The relation between ionophoric nature and cytotoxicity

被引：12

作者：

Hioki, H

Yoshio, S

Motosue, M

Oshita, Y

Nakamura, Y

Mishima, D

Fukuyama, Y

Kodama, M ^{[1
]}

Ueda, K

Katsu, T

机构：

[1] Tokushima Bunri Univ, Fac Pharmaceut Sci, Yamashiro, Tokushima 7708514, Japan

[2] Okayama Univ, Fac Pharmaceut Sci, Okayama 7008530, Japan

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 06期

关键词：

D O I：

10.1021/ol036471i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Enantioselective synthesis of eurylene, 14-deacetyl eurylene, and their 11-epimers was achieved. The characteristic structural feature of these compounds is two tetrahydrofuran (THF) rings substituted in different stereochemistry. The synthetic approach involves nonstereoselective THF ring formation to afford both segments from a common precursor. We also investigated their ionophoric nature and cytotoxicity. The complexation of these compounds with V might be related to their cytotoxic activity.

引用

页码：961 / 964

页数：4

共 28 条

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[2] A STEREOCONTROLLED SYNTHESIS OF THE LEFT HAND (C-1-C-12) SEGMENT OF EURYLENE [J].