Cytotoxic ent-kaurane diterpenoids from isodon rubescens var. rubescens

被引：16

作者：

Han, QB

Xiang, W

Li, RT

Li, ML

Li, SW

Sun, HD ^{[1
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources W China, Kunming 650204, Peoples R China

[2] Kunming Med Coll, Yunnan Pharmaceut Lab Nat Prod, Kunming, Peoples R China

来源：

PLANTA MEDICA | 2004年 / 70卷 / 03期

关键词：

D O I：

10.1055/s-2004-818922

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five new ent-kauranoids, xindongnins C - G (1 - 5), together with five known ones, xindongnins A and B (6 and 7), melissoidesin G (8), dawoensin A (9), and glabcensin V (10), were isolated from the leaves of Isodon rubescens var. rubescens, and structurally elucidated. Compounds 1, 4, and 6 - 10 showed inhibitory effects against human tumor K562 cells with IC50 values ranging from 0.3 to 7.3 mug/mL. The structure of 6 was revised on the basis of its 2D-NMR spectral data.

引用

页码：269 / 272

页数：4

共 13 条

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