Iscoms with different quillaja saponin components differ in their immunomodulating activities

被引：20

作者：

Johansson, M

Lövgren-Bengtsson, K

机构：

[1] Natl Vet Inst, Dept Virol, S-75123 Uppsala, Sweden

[2] Swedish Univ Agr Sci, Dept Vet Microbiol, Sect Virol, Uppsala, Sweden

来源：

VACCINE | 1999年 / 17卷 / 22期

关键词：

iscom; Quillaja saponin; immunomodulation;

D O I：

10.1016/S0264-410X(99)00128-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this study we demonstrate that iscoms made with different defined fractions of quillaja saponins (fractions A and C) exhibit strikingly different immunomodulatory activities. Fraction A has a potent immunomodulatory activity by enhancing antigen specific proliferation and production of IL-2 and IFN-gamma, interestingly, this is not reflected by increased levels of IgG2a. The C-fraction on the other hand strongly enhance antibody production and has the ability to modulate the IgG subclass pattern towards IgG2a, in spite of the fact that C-iscoms induce only low levels of IFN-gamma. Iscoms containing both fractions A and C (Iscoprep(TM)703) induced higher serum antibody responses than iscoms made of either of the fractions alone and showed an enhanced ability to modulate the serum subclass pattern towards IgG2a compared to C-iscoms. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2894 / 2900

页数：7

共 30 条

[1] In vivo and in vitro induction of IL-6 by Quillaja saponaria Molina triterpenoid formulations [J].