Correlation of interleukin-6 serum levels with bone density in postmenopausal women

被引：46

作者：

Papadopoulos, NG ^{[1
]}

Georganas, K ^{[1
]}

Skoutellas, V ^{[1
]}

Konstantellos, E ^{[1
]}

Lyritis, GP ^{[1
]}

机构：

[1] UNIV ATHENS,TH GAROFALIDES RES CTR,KIFISIA 14561,GREECE

来源：

CLINICAL RHEUMATOLOGY | 1997年 / 16卷 / 02期

关键词：

bone density; bone markers; osteoporosis; cytokines; interleukin-6;

D O I：

10.1007/BF02247845

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In order to identify possible correlations between interleukin-6 (IL-6) and hormonal and biochemical parameters of bone metabolism, or bone density, 24 postmenopausal women were studied. Serum IL-6, estradiol, calcium, phosphorus, osteocalcin, alkaline phosphatase, the urinary secretion of calcium, phosphorus and hydroxyproline, and bone density of the lumbar spine, femur and radius were measured. No significant correlation was found between IL-6 and the biochemical parameters. A negative correlation was found between IL-6 and serum estradiol, as well as between IL-6 and bone density in 5 out of 6 sites studied. It is possible that women with high IL-6 levels, may develop lower bone mass.

引用

页码：162 / 165

页数：4

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