Update on the role of Interleukin 17 in rheumatologic autoimmune diseases

被引：53

作者：

Konya, Christine ^{[1
]}

Paz, Ziv ^{[1
]}

Apostolidis, Sokratis A. ^{[1
]}

Tsokos, George C. ^{[1
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Rheumatol, Boston, MA 02215 USA

来源：

CYTOKINE | 2015年 / 75卷 / 02期

关键词：

Interleukin-17; Autoimmune diseases; Biological agents; DELTA-T-CELLS; ROR-GAMMA-T; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ACTIVE PSORIATIC-ARTHRITIS; COLLAGEN-INDUCED ARTHRITIS; ANTI-INTERLEUKIN-17; MONOCLONAL-ANTIBODY; SEVERE PLAQUE PSORIASIS; NECROSIS-FACTOR-ALPHA; NF-KAPPA-B; DOUBLE-BLIND;

D O I：

10.1016/j.cyto.2015.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Interleukin 17 is a proinflammatory cytokine produced by CD4+ T cells when in the presence of a distinct set of cytokines and other cells. Preclinical and clinical studies have assigned a role to IL-17 in tissue inflammation and damage in patients with rheumatoid arthritis, psoriasis and psoriatic arthritis, ankylosing spondylitis and systemic lupus erythematosus. Antibodies blocking the action of IL-17 have already been approved to treat patients with psoriasis and it is expected that they may also benefit patients with other rheumatic diseases. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：207 / 215

页数：9

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