The use of mifepristone in the treatment of neuropsychiatric disorders

被引：77

作者：

DeBattista, C ^{[1
]}

Belanoff, J ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Stanford, CA 94305 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2006年 / 17卷 / 03期

关键词：

D O I：

10.1016/j.tem.2006.02.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mifepristone is a potent glucocorticoid and progesterone receptor antagonist. The pathophysiology of a number of neuropsychiatric disorders implicates abnormalities in glucocorticoid function. These include mood disorders such as psychotic major depression and bipolar depression. In addition, cognitive disorders such as Alzheimer's disease might also be partially mediated by abnormalities in the hypothalamic-pituitary-adrenal axis. Preliminary studies suggest that mifepristone might have a role in the treatment of a number of neuropsychiatric disorders.

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页码：117 / 121

页数：5

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