Tenofovir diphosphate is a poor substrate and a weak inhibitor of rat DNA polymerases α,δ, and ε

被引：31

作者：

Birkus, G

Hájek, M

Kramata, P

Votruba, I

Holy, A

Otová, B

机构：

[1] Acad Sci Czech Republ, Inst Organ Chem & Biochem, Prague, Czech Republic

[2] Charles Univ Prague, Fac Med 1, Inst Biol & Med Genet, Prague, Czech Republic

[3] Charles Univ Prague, Gen Teaching Hosp, Prague, Czech Republic

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 05期

关键词：

D O I：

10.1128/AAC.46.5.1610-1613.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Tenofovir diphosphate (PMPApp) is a weak inhibitor of DNA polymerases (pol) alpha, delta, and epsilon*, with values for the K-i for PMPApp (K-PMPAApp(i)) relative to the K-m for dATP (K-dATP(m)) of 10.2, 10.2, and 15.2, respectively. Its incorporation into DNA was about 1,000-fold less efficient than that of dATP, with K-PMPApp(m) values 350-, 2,155-, and 187-fold higher than K-dATP(m) values for pol alpha, delta, and epsilon*, respectively.

引用

页码：1610 / 1613

页数：4

共 31 条

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