Evolving concepts in the pathogenesis of hairy-cell leukaemia

被引：73

作者：

Tiacci, Enrico

Liso, Arcangelo

Piris, Miguel

Falini, Brunangelo

机构：

[1] Univ Perugia, Inst Hematol, I-06100 Perugia, Italy

[2] Univ Foggia, Inst Hematol, Foggia, Italy

[3] CNIO, Mol Pathol Program, Madrid, Spain

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 06期

关键词：

D O I：

10.1038/nrc1888

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hairy- cell leukaemia ( HCL) has long been recognized as distinct from other chronic B- cell malignancies, but several questions remain unanswered. What is the HCL cell of origin? Why does HCL lack the hallmarks of most mature B- cell tumours ( for example, chromosomal translocations and consistent lymph node involvement) and show unique features like `hairy' morphology and bone-marrow fibrosis? Gene- expression profiling and other studies have recently provided new insights into HCL biology and have the potential to affect clinical practice.

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收藏

页码：437 / 448

页数：12

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