Faecalibacterium prausnitzii and human intestinal health

被引：833

作者：

Miquel, S. ^{[1
,2
]}

Martín, R. ^{[1
,2
]}

Rossi, O. ^{[3
]}

Bermudez-Humaran, L. G. ^{[1
,2
]}

Chatel, J. M. ^{[1
,2
]}

Sokol, H. ^{[1
,2
,4
,5
]}

Thomas, M. ^{[1
,2
]}

Wells, J. M. ^{[3
]}

Langella, P. ^{[1
,2
]}

机构：

[1] INRA, Commensal & Probiot Host Interact Lab, UMR Micalis 1319, F-78350 Jouy En Josas, France

[2] AgroParisTech, Micalis UMR1319, F-78350 Jouy En Josas, France

[3] Wageningen Univ, NL-6700 AH Wageningen, Netherlands

[4] Univ Paris 06, ERL, INSERM,Fac Med St Antoine, U 1057,UMR7203, Paris 6, France

[5] AP HP, Hop St Antoine, Serv Gastroenterol, Paris, France

来源：

CURRENT OPINION IN MICROBIOLOGY | 2013年 / 16卷 / 03期

关键词：

16S RIBOSOMAL-RNA; MUCOSA-ASSOCIATED MICROBIOTA; BUTYRATE-PRODUCING BACTERIA; ACTIVE CROHNS-DISEASE; GUT MICROBIOTA; ULCERATIVE-COLITIS; FUSOBACTERIUM-PRAUSNITZII; FECAL MICROBIOTA; ORAL TOLERANCE; FERMENTATION;

D O I：

10.1016/j.mib.2013.06.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Faecalibacterium prausnitzii is the most abundant bacterium in the human intestinal microbiota of healthy adults, representing more than 5% of the total bacterial population. Over the past five years, an increasing number of studies have clearly described the importance of this highly metabolically active commensal bacterium as a component of the healthy human microbiota. Changes in the abundance of F. prausnitzii have been linked to dysbiosis in several human disorders. Administration of F. prausnitzii strain A2-165 and its culture supernatant have been shown to protect against 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice. Here, we discuss the role of F. prausnitzii in balancing immunity in the intestine and the mechanisms involved.

引用

页码：255 / 261

页数：7

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