Management of rhesus isoimmunization by preimplantation genetic diagnosis

被引：15

作者：

Avner, Rachel ^{[1
]}

Reubinoff, Benjamin E. ^{[2
]}

Simon, Alex ^{[3
]}

Zentner, Bat-Sheva ^{[3
]}

Friedmann, Adam ^{[1
]}

Mitrani-Rosenbaum, Stella ^{[1
]}

Laufer, Neri ^{[3
]}

机构：

[1] Hadassah Univ Hosp, Unit Mol Biol & Genet Engn, POB 24035, IL-91240 Jerusalem, Israel

[2] Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91120 Jerusalem, Israel

[3] Hadassah Univ Hosp, Dept Obstet & Gynecol, IL-91240 Jerusalem, Israel

来源：

MOLECULAR HUMAN REPRODUCTION | 1996年 / 2卷 / 01期

关键词：

D O I：

10.1093/molehr/2.1.60

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A genetic assay by single blastomere analysis was developed for rhesus (RhD) blood group typing of early cleavage stage embryos. The method, which is based on the simultaneous amplification of an RhD-specific sequence and an internal control in single cells, was applied for the selective transfer of RhD-negative embryos in a family of an RhD sensitized woman and a heterozygote partner. The RhD status of two out of three biopsied embryos was determined. According to their amplified products, both were typed as RhD-negative and transferred to the uterus. Pregnancy was not achieved.

引用

页码：60 / 62

页数：3

共 11 条

[1] PRENATAL DETERMINATION OF FETAL RHD TYPE BY DNA AMPLIFICATION [J].

BENNETT, PR ;

KIM, CL ;

COLIN, Y ;

WARWICK, RM ;

CHERIFZAHAR, B ;

FISK, NM ;

CARTRON, JP .

NEW ENGLAND JOURNAL OF MEDICINE, 1993, 329 (09) :607-610

[2]

BENSHUSHAN A, 1993, FERTIL STERIL, V59, P1065

[3] EPIDEMIOLOGY OF RH HEMOLYTIC-DISEASE OF THE NEWBORN IN THE UNITED-STATES [J].

CHAVEZ, GF ;

MULINARE, J ;

EDMONDS, LD .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1991, 265 (24) :3270-3274

[4] MOLECULAR-CLONING AND PROTEIN-STRUCTURE OF A HUMAN BLOOD-GROUP RH POLYPEPTIDE [J].

CHERIFZAHAR, B ;

BLOY, C ;

LEVANKIM, C ;

BLANCHARD, D ;

BAILLY, P ;

HERMAND, P ;

SALMON, C ;

CARTRON, JP ;

COLIN, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (16) :6243-6247

[5]

FINDLAY I, 1995, HUM REPROD, V10, P1005

[6] DERIVATION OF NEW MATHEMATIC FORMULAS FOR DETERMINING WHETHER A D-POSITIVE FATHER IS HETEROZYGOUS OR HOMOZYGOUS FOR THE D-ANTIGEN [J].

KANTER, MH .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1992, 166 (01) :61-63

[7] MOLECULAR-CLONING AND PRIMARY STRUCTURE OF THE HUMAN BLOOD-GROUP RHD POLYPEPTIDE [J].

LEVANKIM, C ;

MOURO, I ;

CHERIFZAHAR, B ;

RAYNAL, V ;

CHERRIER, C ;

CARTRON, JP ;

COLIN, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (22) :10925-10929

[8]

MALTER HE, 1989, FERTIL STERIL, V51, P139

[9] MOLECULAR-GENETIC BASIS OF THE HUMAN RHESUS BLOOD-GROUP SYSTEM [J].

MOURO, I ;

COLIN, Y ;

CHERIFZAHAR, B ;

CARTRON, JP ;

LEVANKIM, C .

NATURE GENETICS, 1993, 5 (01) :62-65

[10]

Reubinoff B.E., 1995, AM J OBSTET GYNECOL

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