Patterns of oncogene activation in human neuroblastoma cells

被引：17

作者：

Corvi, R

Savelyeva, L

Schwab, M

机构：

[1] Deutsches Krebsforschungszentrum, Abteilung Zytogenetik, D-69120 Heidelberg

来源：

JOURNAL OF NEURO-ONCOLOGY | 1997年 / 31卷 / 1-2期

关键词：

oncogenes; FISH; tumorigenesis; neuroblastoma; N-MYC; MDM2; amplification; duplication;

D O I：

10.1023/A:1005721027709

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human neuroblastoma is the most frequent solid tumor in children. Recent studies suggest that a multiplicity of genomic alterations contributes to neuroblastoma, the most frequent and well studied being deletion of the short arm of chromosome 1 and amplification of N-MYC. We here present and discuss different patterns of oncogene activation including, amplification of N-MYC, duplication of N-MYC and amplification of MDM2.

引用

收藏

页码：25 / 31

页数：7

相关论文

共 39 条

[1] ONCOGENE AMPLIFICATION IN TUMOR-CELLS [J].

ALITALO, K ;

SCHWAB, M .

ADVANCES IN CANCER RESEARCH, 1986, 47 :235-281

[2] AMPLIFIED N-MYC IN HUMAN NEURO-BLASTOMA CELLS IS OFTEN ARRANGED AS CLUSTERED TANDEM REPEATS OF DIFFERENTLY RECOMBINED DNA [J].

AMLER, LC ;

SCHWAB, M .

MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (11) :4903-4913

[3]

Bertheir F., 1990, Computational Intelligence, II. Proceedings of the International Symposium `Computational Intelligence 89', P1

[4] AMPLIFICATION OF N-MYC IN UNTREATED HUMAN NEUROBLASTOMAS CORRELATES WITH ADVANCED DISEASE STAGE [J].

BRODEUR, GM ;

SEEGER, RC ;

SCHWAB, M ;

VARMUS, HE ;

BISHOP, JM .

SCIENCE, 1984, 224 (4653) :1121-1124

[5]

CARON H, UNPUB ALLELIC LOSS C

[6]

CHRISTIANSEN H, 1989, MONATSSCHR KINDERH, V137, P666

[7]

COHN SL, 1990, ONCOGENE, V5, P1821

[8]

CORVI R, 1995, ONCOGENE, V10, P1081

[9] MYCN IS RETAINED IN SINGLE-COPY AT CHROMOSOME-2 BAND-P23-24 DURING AMPLIFICATION IN HUMAN NEUROBLASTOMA-CELLS [J].

CORVI, R ;

AMLER, LC ;

SAVELYEVA, L ;

GEHRING, M ;

SCHWAB, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (12) :5523-5527

[10] CYTOGENETIC EVOLUTION OF MYCN AND MDM2 AMPLIFICATION IN THE NEUROBLASTOMA LS TUMOR AND ITS CELL-LINE [J].

CORVI, R ;

SAVELYEVA, L ;

AMLER, L ;

HANDGRETINGER, R ;

SCHWAB, M .

EUROPEAN JOURNAL OF CANCER, 1995, 31A (04) :520-523

← 1 2 3 4 →