Tetrabutylammonium Tetra(tert-Butyl Alcohol)-Coordinated Fluoride as a Facile Fluoride Source

被引：196

作者：

Kim, Dong Wook ^{[1
]}

Jeong, Hwan-Jeong ^{[1
]}

Lim, Seok Tae ^{[1
]}

Sohn, Myung-Hee ^{[1
]}

机构：

[1] Chonbuk Natl Univ, Sch Med, Cyclotron Res Ctr, Dept Nucl Med, Jeonju 561712, Jeonbuk, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 44期

关键词：

alcohols; fluorination; fluorine; nucleophilic substitution; tetrabutylammonium fluoride;

D O I：

10.1002/anie.200803150

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) F- on: The title compound TBAF(tBuOH) 4 can act as a highly effective fluoride source for nucleophilic fluorination thanks to its favorable properties, such as a stable structure (in which the fluoride ion is surrounded by four bulky nonpolar protic alcohol molecules), a dehydrated state, low hygroscopicity, good solubility in organic solvents, good nucleophilicity, and low basicity. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：8404 / 8406

页数：3

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