Antisense properties of morpholino oligomers

被引:16
作者
Summerton, J [1 ]
Weller, D [1 ]
机构
[1] ANTIVIRALS INC,CORVALLIS,OR 97333
来源
NUCLEOSIDES & NUCLEOTIDES | 1997年 / 16卷 / 7-9期
关键词
D O I
10.1080/07328319708006105
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Morpholino oligomers are third generation antisense agents designed to be cost effective, water soluble and resistant to nuclease attack. They show high potency and sequence specificity and follow predictable targeting rules when used in antisense applications in cell culture.
引用
收藏
页码:889 / 898
页数:10
相关论文
共 34 条
[1]  
BELIKOVA A, 1967, TETRAHEDRON LETT, V7, P3557
[2]   AN ASSESSMENT OF THE ANTISENSE PROPERTIES OF RNASE H-COMPETENT AND STERIC-BLOCKING OLIGOMERS [J].
BONHAM, MA ;
BROWN, S ;
BOYD, AL ;
BROWN, PH ;
BRUCKENSTEIN, DA ;
HANVEY, JC ;
THOMSON, SA ;
PIPE, A ;
HASSMAN, F ;
BISI, JE ;
FROEHLER, BC ;
MATTEUCCI, MD ;
WAGNER, RW ;
NOBLE, SA ;
BABISS, LE .
NUCLEIC ACIDS RESEARCH, 1995, 23 (07) :1197-1203
[3]   ENZYMATIC AMPLIFICATION OF TRANSLATION INHIBITION OF RABBIT BETA-GLOBIN MESSENGER-RNA MEDIATED BY ANTI-MESSENGER OLIGODEOXYNUCLEOTIDES COVALENTLY LINKED TO INTERCALATING AGENTS [J].
CAZENAVE, C ;
LOREAU, N ;
THUONG, NT ;
TOULME, JJ ;
HELENE, C .
NUCLEIC ACIDS RESEARCH, 1987, 15 (12) :4717-4736
[4]   COMPARATIVE INHIBITION OF RABBIT GLOBIN MESSENGER-RNA TRANSLATION BY MODIFIED ANTISENSE OLIGODEOXYNUCLEOTIDES [J].
CAZENAVE, C ;
STEIN, CA ;
LOREAU, N ;
THUONG, NT ;
NECKERS, LM ;
SUBASINGHE, C ;
HELENE, C ;
COHEN, JS ;
TOULME, JJ .
NUCLEIC ACIDS RESEARCH, 1989, 17 (11) :4255-4273
[5]  
Crouch R. J., 1982, NUCLEASES, P211
[6]   THE UPTAKE AND DISTRIBUTION OF PHOSPHOROTHIOATE OLIGONUCLEOTIDES INTO VASCULAR SMOOTH-MUSCLE CELLS IN-VITRO AND IN RABBIT ARTERIES [J].
FARRELL, CL ;
BREADY, JV ;
KAUFMAN, SA ;
QIAN, YX ;
BURGESS, TL .
ANTISENSE RESEARCH AND DEVELOPMENT, 1995, 5 (03) :175-183
[7]   PHOSPHORAMIDATE ANALOGS OF DNA - SYNTHESIS AND THERMAL-STABILITY OF HETERODUPLEXES [J].
FROEHLER, B ;
NG, P ;
MATTEUCCI, M .
NUCLEIC ACIDS RESEARCH, 1988, 16 (11) :4831-4839
[8]   EFFECTS OF PHOSPHOROTHIOATE CAPPING ON ANTISENSE OLIGONUCLEOTIDE STABILITY, HYBRIDIZATION AND ANTIVIRAL EFFICACY VERSUS HERPES-SIMPLEX VIRUS-INFECTION [J].
HOKE, GD ;
DRAPER, K ;
FREIER, SM ;
GONZALEZ, C ;
DRIVER, VB ;
ZOUNES, MC ;
ECKER, DJ .
NUCLEIC ACIDS RESEARCH, 1991, 19 (20) :5743-5748
[9]  
HUDZIAK RM, 1996, INP RESS ANTISENSE R
[10]  
HUDZIAK RM, UNPUB