Ultrastructural localization of Sm15 and Sm25, two major tegumental adult worm antigens of Schistosoma mansoni

被引：5

作者：

Abath, FGC

Hirst, EMA

Hagan, P

Simpson, AJG

机构：

[1] Fiocruz MS, Inst Aggeu Magalhaes, Fundacao Oswaldo Cruz, BR-50670420 Recife, PE, Brazil

[2] Natl Inst Med Res, London NW7 1AA, England

[3] Univ Glasgow, Dept Infect & Immunity, IBLS, Glasgow G12 8QQ, Lanark, Scotland

[4] Inst Ludwig Pesquisas Sobre O Canc, BR-01509010 Sao Paulo, Brazil

来源：

PARASITE | 1999年 / 6卷 / 03期

关键词：

schistosoma mansoni; tegumental antigens; immunolocalization; Sm25; Sm15;

D O I：

10.1051/parasite/1999063243

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

Sm15 and Sm25 are two of the principal tegumental antigens recognized by antibodies from mice protectively vaccinated with adult worm tegumental membranes and may therefore be potential vaccine candidate antigens. Using antibodies affinity purified from anti-tegumental membrane anti-sera, and antibodies raised against the recombinant antigens, Sm15 and Sm25 were shown to be located specifically in the tegument of adult worms being distributed throughout the syncitium but not associated with the outer membrane.

引用

页码：243 / 247

页数：5

共 20 条

[1]

STRUCTURE OF THE GENE ENCODING A PUTATIVE SCHISTOSOMA-MANSONI TEGUMENTAL ANTIGEN PRECURSOR [J].