Multiplexed RNA trafficking in oligodendrocytes and neurons

被引：43

作者：

Carson, John H. ^{[2
]}

Gao, Yuanzheng ^{[2
]}

Tatavarty, Vedakumar ^{[2
]}

Levin, Mikhail K. ^{[2
]}

Korza, George ^{[2
]}

Francone, Victor P. ^{[1
]}

Kosturko, Linda D. ^{[1
]}

Maggipinto, Michael J. ^{[1
]}

Barbarese, Elisa ^{[1
]}

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Neurosci, Farmington, CT 06030 USA

[2] Univ Connecticut, Ctr Hlth, Dept Mol Microbial & Struct Biol, Farmington, CT 06030 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2008年 / 1779卷 / 08期

关键词：

HnRNP A2; myelin; RNA granule; synapse; TOG;

D O I：

10.1016/j.bbagrm.2008.04.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In oligodendrocytes and neurons genetic information is transmitted from the nucleus to dendrites in the form of RNA granules. Here we describe how transport of multiple different RNA molecules in individual granules is analogous to the process of multiplexing in telecommunications. In both cases multiple messages are combined into a composite signal for transmission on a single carrier. Multiplexing provides a mechanism to coordinate local expression of ensembles of genes in myelin in oligodendrocytes and at synapses in neurons. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：453 / 458

页数：6

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