Antifungal Saponins from Paris polyphylla Smith

被引:103
作者
Deng, Dawei [1 ]
Lauren, Denis R. [1 ]
Cooney, Janine M. [1 ]
Jensen, Dwayne J. [1 ]
Wurms, Kirstin V. [1 ]
Upritchard, Jenine E. [2 ]
Cannon, Richard D. [2 ]
Wang, Ming Zhong [3 ]
Li, Ming Zhang [3 ]
机构
[1] HortResearch, Ruakura Agr Res Ctr, Hamilton, New Zealand
[2] Univ Otago, Dept Oral Sci, Dunedin, New Zealand
[3] Sichuan Prov Nat Resources Res Inst, Chengdu, Sichuan, Peoples R China
关键词
saponins; pennogenin; Liliaceae; Paris polyphylla; antifungal activity;
D O I
10.1055/s-2008-1081345
中图分类号
Q94 [植物学];
学科分类号
071001 [植物学];
摘要
Three steroidal saponins, including one new and two known compounds, were isolated from the rhizomes of Paris polyphylla Smith. One- and two-dimensional NMR, LC-MS, and interpretation of hydrolytic cleavage experiments led to the identification of the structure of the new saponin as (25R)-spirost-5-ene-3 beta,17 alpha-diol (pennogenin) 3-O-{O-alpha-L-rhamnopyranosyl-(1 -> 2)-O-[O-beta-xylopyranosyl-(1 -> 5)-alpha-L-arabinofuranosyl-(1 -> 4)]-beta-D-glucopyranoside}. The isolated saponins were evaluated for their antifungal activity against Cladosporium cladosporioides and Candida species and showed comparable activity to chemicals used in some commercial products.
引用
收藏
页码:1397 / 1402
页数:6
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