Oxidative transformation of a naturally occurring okadaic acid diol ester by the diatom Thalassiosira weissflogii

被引：7

作者：

Hu, TM

Burton, I

Curtis, JM

Quilliam, MA

Walter, JA

Windust, AJ

Wright, JLC

机构：

[1] Natl Res Council Canada, Inst Marine Biosci, Halifax, NS B3H 3Z1, Canada

[2] Dalhousie Univ, Dept Biol, Halifax, NS B3H 4JI, Canada

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 21期

关键词：

diarrhetic shellfish poison; DSP; okadaic acid; dinoflagellate; Prorocentrum lima; diatom; Thalassiosira weissflogii;

D O I：

10.1016/S0040-4039(99)00516-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diarrhetic shellfish poisoning (DSP) toxin okadaic acid (1) is found in extracts of the dinoflagellate Prorocentrum lima together with a suite of diol esters such as 2. When 2 Mras added to the culture medium of the centric diatom Thalassiosira weissflogii, it was transformed into a range of products within three days. Three of these products, 3, 4 and 5, were isolated from the medium and identified as oxidation products of 2, suggesting that the diatom produces DSP metabolites of greater polarity as a means of detoxification. In addition, another diol ester product 6 was identified as a minor impurity of 2. Crown copyright (C) 1999 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：3981 / 3984

页数：4

共 10 条

[1] OKADAIC ACID - A NEW PROBE FOR THE STUDY OF CELLULAR-REGULATION [J].