The genetics of cardiovascular disease

被引：10

作者：

Delles, Christian ^{[1
]}

McBride, Martin W. ^{[1
]}

Padmanabhan, Sandosh ^{[1
]}

Dominiczak, Anna F. ^{[1
]}

机构：

[1] Univ Glasgow, Fac Med, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2008年 / 19卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/j.tem.2008.07.010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models, and the translation of these findings to human disease is an exciting challenge. There is a trend towards large-scale genome-wide association studies that are subject to strict quality criteria with regard to both genotyping and phenotyping. Here, we review some of the strategies that have been developed to translate findings from experimental models to human disease and outline the need for optimizing global approaches to analyze such results. Findings from ongoing studies are interpreted in the context of disease pathways instead of the more traditional focus on single genetic variants.

引用

页码：309 / 316

页数：8

共 73 条

[1] Tnull and Mnull genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking [J].

Abu-Amero, KK ;

Al-Boudari, OM ;

Mohamed, GH ;

Dzimiri, N .

BMC MEDICAL GENETICS, 2006, 7

[2] Progress and prospects in rat genetics: a community view [J].

Aitman, Timothy J. ;

Critser, John K. ;

Cuppen, Edwin ;

Dominiczak, Anna ;

Fernandez-Suarez, Xose M. ;

Flint, Jonathan ;

Gauguier, Dominique ;

Geurts, Aron M. ;

Gould, Michael ;

Harris, Peter C. ;

Holmdahl, Rikard ;

Hubner, Norbert ;

Izsvak, Zsuzsanna ;

Jacob, Howard J. ;

Kuramoto, Takashi ;

Kwitek, Anne E. ;

Marrone, Anna ;

Mashimo, Tomoji ;

Moreno, Carol ;

Mullins, John ;

Mullins, Linda ;

Olsson, Tomas ;

Pravenec, Michal ;

Riley, Lela ;

Saar, Kathrin ;

Serikawa, Tadao ;

Shull, James D. ;

Szpirer, Claude ;

Twigger, Simon N. ;

Voigt, Birger ;

Worley, Kim .

NATURE GENETICS, 2008, 40 (05) :516-522

[3] Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk [J].

Benhamou, S ;

Lee, WJ ;

Alexandrie, AK ;

Boffetta, P ;

Bouchardy, C ;

Butkiewicz, D ;

Brockmöller, J ;

Clapper, ML ;

Daly, A ;

Dolzan, V ;

Ford, J ;

Gaspari, L ;

Haugen, A ;

Hirvonen, A ;

Husgafvel-Pursiainen, K ;

Ingelman-Sundberg, M ;

Kalina, I ;

Kihara, M ;

Kremers, P ;

Le Marchand, L ;

London, SJ ;

Nazar-Stewart, V ;

Onon-Kihara, M ;

Rannug, A ;

Romkes, M ;

Ryberg, D ;

Seidegard, J ;

Shields, P ;

Strange, RC ;

Stücker, I ;

To-Figueras, J ;

Brennan, P ;

Taioli, E .

CARCINOGENESIS, 2002, 23 (08) :1343-1350

[4] Angiotensin-converting enzyme gene polymorphism predicts the time-course of blood pressure response to angiotensin converting enzyme inhibition in the AASK trial [J].

Bhatnagar, Vibha ;

O'Connor, Daniel T. ;

Schork, Nicholas J. ;

Salem, Rany M. ;

Nievergelt, Caroline M. ;

Rana, Brinda K. ;

Smith, Douglas W. ;

Bakris, George L. ;

Middleton, John P. ;

Norris, Keith C. ;

Wright, Jackson T. ;

Cheek, Deanna ;

Hiremath, Leena ;

Contreras, Gabriel ;

Appel, Lawrence J. ;

Lipkowitz, Michael S. .

JOURNAL OF HYPERTENSION, 2007, 25 (10) :2082-2092

[5] Genomics - Guilt by association [J].

Bowcock, Anne M. .

NATURE, 2007, 447 (7145) :645-646

[6] Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].

Burton, Paul R. ;

Clayton, David G. ;

Cardon, Lon R. ;

Craddock, Nick ;

Deloukas, Panos ;

Duncanson, Audrey ;

Kwiatkowski, Dominic P. ;

McCarthy, Mark I. ;

Ouwehand, Willem H. ;

Samani, Nilesh J. ;

Todd, John A. ;

Donnelly, Peter ;

Barrett, Jeffrey C. ;

Davison, Dan ;

Easton, Doug ;

Evans, David ;

Leung, Hin-Tak ;

Marchini, Jonathan L. ;

Morris, Andrew P. ;

Spencer, Chris C. A. ;

Tobin, Martin D. ;

Attwood, Antony P. ;

Boorman, James P. ;

Cant, Barbara ;

Everson, Ursula ;

Hussey, Judith M. ;

Jolley, Jennifer D. ;

Knight, Alexandra S. ;

Koch, Kerstin ;

Meech, Elizabeth ;

Nutland, Sarah ;

Prowse, Christopher V. ;

Stevens, Helen E. ;

Taylor, Niall C. ;

Walters, Graham R. ;

Walker, Neil M. ;

Watkins, Nicholas A. ;

Winzer, Thilo ;

Jones, Richard W. ;

McArdle, Wendy L. ;

Ring, Susan M. ;

Strachan, David P. ;

Pembrey, Marcus ;

Breen, Gerome ;

St Clair, David ;

Caesar, Sian ;

Gordon-Smith, Katherine ;

Jones, Lisa ;

Fraser, Christine ;

Green, Elain K. .

NATURE, 2007, 447 (7145) :661-678

[7] Genome-wide mapping of human loci for essential hypertension [J].

Caulfield, M ;

Munroe, P ;

Pembroke, J ;

Samani, N ;

Dominiczak, A ;

Brown, M ;

Benjamin, N ;

Webster, J ;

Ratcliffe, P ;

O'Shea, S ;

Papp, J ;

Taylor, E ;

Dobson, R ;

Knight, J ;

Newhouse, S ;

Hooper, J ;

Lee, W ;

Brain, N ;

Clayton, D ;

Lathrop, GM ;

Farrall, M ;

Connell, J .

LANCET, 2003, 361 (9375) :2118-2123

[8] Replicating genotype-phenotype associations [J].

Chanock, Stephen J. ;

Manolio, Teri ;

Boehnke, Michael ;

Boerwinkle, Eric ;

Hunter, David J. ;

Thomas, Gilles ;

Hirschhorn, Joel N. ;

Abecasis, Goncalo ;

Altshuler, David ;

Bailey-Wilson, Joan E. ;

Brooks, Lisa D. ;

Cardon, Lon R. ;

Daly, Mark ;

Donnelly, Peter ;

Fraumeni, Joseph F., Jr. ;

Freimer, Nelson B. ;

Gerhard, Daniela S. ;

Gunter, Chris ;

Guttmacher, Alan E. ;

Guyer, Mark S. ;

Harris, Emily L. ;

Hoh, Josephine ;

Hoover, Robert ;

Kong, C. Augustine ;

Merikangas, Kathleen R. ;

Morton, Cynthia C. ;

Palmer, Lyle J. ;

Phimister, Elizabeth G. ;

Rice, John P. ;

Roberts, Jerry ;

Rotimi, Charles ;

Tucker, Margaret A. ;

Vogan, Kyle J. ;

Wacholder, Sholom ;

Wijsman, Ellen M. ;

Winn, Deborah M. ;

Collins, Francis S. .

NATURE, 2007, 447 (7145) :655-660

[9] Variations in DNA elucidate molecular networks that cause disease [J].

Chen, Yanqing ;

Zhu, Jun ;

Lum, Pek Yee ;

Yang, Xia ;

Pinto, Shirly ;

MacNeil, Douglas J. ;

Zhang, Chunsheng ;

Lamb, John ;

Edwards, Stephen ;

Sieberts, Solveig K. ;

Leonardson, Amy ;

Castellini, Lawrence W. ;

Wang, Susanna ;

Champy, Marie-France ;

Zhang, Bin ;

Emilsson, Valur ;

Doss, Sudheer ;

Ghazalpour, Anatole ;

Horvath, Steve ;

Drake, Thomas A. ;

Lusis, Aldons J. ;

Schadt, Eric E. .

NATURE, 2008, 452 (7186) :429-435

[10] Quantitative trait loci in genetically hypertensive rats - Possible sex specificity [J].

Clark, JS ;

Jeffs, B ;

Davidson, AO ;

Lee, WK ;

Anderson, NH ;

Bihoreau, MT ;

Brosnan, MJ ;

Devlin, AM ;

Kelman, AW ;

Lindpaintner, K ;

Dominiczak, AF .

HYPERTENSION, 1996, 28 (05) :898-906

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