Systemic Immunometabolism: Challenges and Opportunities

被引：101

作者：

Lercher, Alexander ^{[1
]}

Baazim, Hatoon ^{[1
,2
]}

Bergthaler, Andreas ^{[1
]}

机构：

[1] Austrian Acad Sci, CeMM Res Ctr Mol Med, Lazarettgasse 14 AKH BT25-3, A-1090 Vienna, Austria

[2] Harvard TH Chan Sch Publ Hlth, Sabri Ulker Ctr, Dept Mol Metab, Hotamisligil Lab, Boston, MA USA

来源：

IMMUNITY | 2020年 / 53卷 / 03期

基金：

欧洲研究理事会;

关键词：

PYRUVATE-KINASE M2; CELL EFFECTOR FUNCTION; T-CELLS; ADIPOSE-TISSUE; CANCER CACHEXIA; IMMUNE-SYSTEM; SUCCINATE-DEHYDROGENASE; GENE-EXPRESSION; LARGE-INTESTINE; KETOGENIC DIET;

D O I：

10.1016/j.immuni.2020.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Over the past 10 years, the field of immunometabolism made great strides to unveil the crucial role of intracellular metabolism in regulating immune cell function. Emerging insights into how systemic inflammation and metabolism influence each other provide a critical additional dimension on the organismal level. Here, we discuss the concept of systemic immunometabolism and review the current understanding of the communication circuits that underlie the reciprocal impact of systemic inflammation and metabolism across organs in inflammatory and infectious diseases, as well as how these mechanisms apply to homeostasis. We present current challenges of systemic immunometabolic research, and in this context, highlight opportunities and put forward ideas to effectively explore organismal physiological complexity in both health and disease.

引用

页码：496 / 509

页数：14

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