Structure of the DNA coiled coil formed by d(CGATATATATAT)

被引：14

作者：

De Luchi, D

Tereshko, V

Gouyette, C

Subirana, JA

机构：

[1] Univ Politecn Catalunya, Dept Engn Quim, E-08028 Barcelona, Spain

[2] Univ Chicago, Dept Biochem & Mol Biol, Chicago, IL 60637 USA

[3] Inst Pasteur, F-75724 Paris 15, France

来源：

CHEMBIOCHEM | 2006年 / 7卷 / 04期

关键词：

coiled coils; DNA; oligonucleotides; X-ray crystallography;

D O I：

10.1002/cbic.200500449

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

AT-rich DNA sequences are highly polymorphic and are very abundant in noncoding regions of the genome. We have determined the molecular structure of the coiled coil obtained from d(CGATATATATAT) by single-crystal X-ray diffraction. This oligodeoxynucleotide forms continuous duplexes through its sticky ends. The A-T base pairs are in the Hoogsteen conformation. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：585 / 587

页数：3

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