Potential neuroprotective effects of acamprosate

被引：23

作者：

Koob, GF

Mason, BJ

De Witte, P

Littleton, J

Siggins, GR

机构：

[1] Univ Miami, Sch Med, Dept Psychiat & Behav Sci, Miami, FL 33136 USA

[2] Scripps Res Inst, Dept Neuropharmacol, La Jolla, CA USA

[3] Univ Louvain, B-3001 Louvain, Belgium

[4] Univ Kentucky, Tobacco & Hlth Res Inst, Lexington, KY 40546 USA

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 2002年 / 26卷 / 04期

关键词：

acamprosate; neuroprotective; glutamate; alcoholism;

D O I：

10.1097/00000374-200204000-00021

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

This article re resents the proceedings of a symposium at the 2001 RSA Meeting in Montreal, Canada. The organizers were Barbara J. Mason and George F. Koob. Anita M. Goodman served as chair. The presentations were (1) Acamprosate inhibits alcohol withdrawal-induced neurotoxicity in organotypic hippocampal cultures, by John Littleton; (2) Acamprosate alteration of NMDA receptor-dependent synaptic transmission and synaptic plasticity, by George R. Siggins; (3) Acamprosare and glutamate during ethanol withdrawal, by Philippe De Witte; (4) Clinical evidence of protective CNS effects of acamprosate in alcohol-dependent individuals. by Barbara J. Mason.

引用

页码：586 / 592

页数：7

共 27 条

[1] Acamprosate is neuroprotective against glutamate-induced excitotoxicity when enhanced by ethanol withdrawal in neocortical cultures of fetal rat brain [J].