Long-term effectiveness against cholera of oral killed whole-cell vaccine produced in Vietnam

被引：63

作者：

Thiem, Vu Dinh

Deen, Jacqueline L.

von Seidlein, Lorenz

Canh, Do Gia

Anh, Dang Duc

Park, Jin-Kyung

Ali, Mohammad

Danovaro-Holliday, M. Carolina

Son, Nguyen Dinh

Hoa, Nguyen Thai

Holmgren, Jan

Clemens, John D.

机构：

[1] Int Vaccine Inst, Seoul, South Korea

[2] Natl Inst Hyg & Epidemiol, Hanoi, Vietnam

[3] Thua Thien Hue Prov Hlth Serv, Hue, Vietnam

[4] Univ Gothenburg, Gothenburg, Sweden

[5] NICHHD, Bethesda, MD 20892 USA

来源：

VACCINE | 2006年 / 24卷 / 20期

关键词：

cholera; vaccine; effectiveness;

D O I：

10.1016/j.vaccine.2006.03.008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

We assessed the long-term protection afforded by a killed whole-cell oral cholera vaccine produced in Vietnam. A mass immunization of children and adults with the killed whole-cell oral cholera vaccine was undertaken in half of the communes of Hue, Vietnam, in 1998; the remaining communes were immunized in 2000. No cholera was observed in Hue until 2003, when an outbreak of El Tor cholera made it possible to conduct a case-control study. The overall vaccine effectiveness 3-5 years after vaccination was 50% (9-63%). This low-cost, easily administered vaccine should be considered as a tool for the control of cholera. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：4297 / 4303

页数：7

共 12 条

[1]

Herd immunity conferred by killed oral cholera vaccines in Bangladesh: a reanalysis [J].