Efficacy of CDDP and AGM-1470 chemotherapy against lung metastasis in rat osteosarcoma depends on the timing of combined administration

被引：4

作者：

Morishita, T

Mii, Y

Miyauchi, Y

Miura, S

Honoki, K

Aoki, M

Kido, A

Tamai, S

Tsutsumi, M

Konishi, Y

机构：

[1] Department of Orthopedic Surgery, Cancer Center, Nara Medical University, Nara

[2] Department of Oncological Pathology, Cancer Center, Nara Medical University, Nara

[3] Departments of Orthopedic Surgery, Kashihara, Nara 634

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 1997年 / 27卷 / 04期

关键词：

rat osteosarcoma; AGM-1470; CDDP; metastasis; combination therapy;

D O I：

10.1093/jjco/27.4.236

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The efficacy of combination therapy with cis-diammine-dichloroplatinum (II) (CDDP) and o-(chloroacetyl-carbomoyl) fumagillol (AGM-1470) was evaluated experimentally using a transplantable rat osteosarcoma line, previously established in our laboratory, with a high potential for metastasis. Tumor-bearing male Fischer 344 rats were administered CDDP (2.5 mg/kg) together with, or after discontinuation of, AGM-1470 treatment (10 mg/kg/body weight/week). When CDDP was administered three days after discontinuation of AGM-1470 the most pronounced antimetastatic effects were observed, although the antitumor effect was approximately the same.

引用

页码：236 / 239

页数：4

共 23 条

[1]

FOLKMAN J, 1974, CANCER RES, V34, P2109

[2] TUMOR ANGIOGENESIS [J].