MicroRNAs as oncogenes

被引：322

作者：

Hammond, SM ^{[1
]}

机构：

[1] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Cell & Dev Biol, Chapel Hill, NC 27599 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2006年 / 16卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/j.gde.2005.12.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

MicroRNAs (miRNAs) are a class of non-coding RNAs that function as endogenous triggers of the RNA interference pathway. Originally discovered in Caenorhabditis elegans, this group of tiny RNAs has moved to the forefront of biology. With over 300 miRNA genes identified in the human genome, and a plethora of predicted mRNA targets, it is believed that these small RNAs have a central role in diverse cellular and developmental processes. Concordant with this, aberrant expression of miRNA genes could lead to human disease, including cancer. Although the connection of miRNAs with cancer has been suspected for several years, four recent studies have confirmed the suspicion that miRNAs; regulate cell proliferation and apoptosis, and play a role in cancer.

引用

页码：4 / 9

页数：6

共 41 条

[1] Therapeutic implications of cancer stem cells [J].

Al-Hajj, M ;

Becker, MW ;

Wichal, M ;

Weissman, I ;

Clarke, MF .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2004, 14 (01) :43-47

[2] Myc-mediated proliferation and lymphomagenesis, but not apoptosis, are compromised by E2F1 loss [J].

Baudino, TA ;

Maclean, KH ;

Brennan, J ;

Parganas, E ;

Yang, CY ;

Aslanian, A ;

Lees, JA ;

Sherr, CJ ;

Roussel, MF ;

Cleveland, JL .

MOLECULAR CELL, 2003, 11 (04) :905-914

[3] Identification of hundreds of conserved and nonconserved human microRNAs [J].

Bentwich, I ;

Avniel, A ;

Karov, Y ;

Aharonov, R ;

Gilad, S ;

Barad, O ;

Barzilai, A ;

Einat, P ;

Einav, U ;

Meiri, E ;

Sharon, E ;

Spector, Y ;

Bentwich, Z .

NATURE GENETICS, 2005, 37 (07) :766-770

[4] Phylogenetic shadowing and computational identification of human microRNA genes [J].

Berezikov, E ;

Guryev, V ;

van de Belt, J ;

Wienholds, E ;

Plasterk, RHA ;

Cuppen, E .

CELL, 2005, 120 (01) :21-24

[5] Principles of MicroRNA-target recognition [J].

Brennecke, J ;

Stark, A ;

Russell, RB ;

Cohen, SM .

PLOS BIOLOGY, 2005, 3 (03) :404-418

[6] A computational view of microRNAs and their targets [J].

Brown, JR ;

Sanseau, P .

DRUG DISCOVERY TODAY, 2005, 10 (08) :595-601

[7] Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia [J].

Calin, GA ;

Dumitru, CD ;

Shimizu, M ;

Bichi, R ;

Zupo, S ;

Noch, E ;

Aldler, H ;

Rattan, S ;

Keating, M ;

Rai, K ;

Rassenti, L ;

Kipps, T ;

Negrini, M ;

Bullrich, F ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (24) :15524-15529

[8] Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [J].

Calin, GA ;

Sevignani, C ;

Dan Dumitru, C ;

Hyslop, T ;

Noch, E ;

Yendamuri, S ;

Shimizu, M ;

Rattan, S ;

Bullrich, F ;

Negrini, M ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :2999-3004

[9] The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis [J].

Carmell, MA ;

Xuan, ZY ;

Zhang, MQ ;

Hannon, GJ .

GENES & DEVELOPMENT, 2002, 16 (21) :2733-2742

[10] The transcriptional landscape of the mammalian genome [J].

Carninci, P ;

Kasukawa, T ;

Katayama, S ;

Gough, J ;

Frith, MC ;

Maeda, N ;

Oyama, R ;

Ravasi, T ;

Lenhard, B ;

Wells, C ;

Kodzius, R ;

Shimokawa, K ;

Bajic, VB ;

Brenner, SE ;

Batalov, S ;

Forrest, ARR ;

Zavolan, M ;

Davis, MJ ;

Wilming, LG ;

Aidinis, V ;

Allen, JE ;

Ambesi-Impiombato, X ;

Apweiler, R ;

Aturaliya, RN ;

Bailey, TL ;

Bansal, M ;

Baxter, L ;

Beisel, KW ;

Bersano, T ;

Bono, H ;

Chalk, AM ;

Chiu, KP ;

Choudhary, V ;

Christoffels, A ;

Clutterbuck, DR ;

Crowe, ML ;

Dalla, E ;

Dalrymple, BP ;

de Bono, B ;

Della Gatta, G ;

di Bernardo, D ;

Down, T ;

Engstrom, P ;

Fagiolini, M ;

Faulkner, G ;

Fletcher, CF ;

Fukushima, T ;

Furuno, M ;

Futaki, S ;

Gariboldi, M .

SCIENCE, 2005, 309 (5740) :1559-1563

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