The regulation of AP-1 activity by mitogen-activated protein kinases

被引：119

作者：

Karin, M

机构：

[1] Department of Pharmacology, Program in Biomedical Sciences, University of California, San Diego School of Medicine, San Diego, CA 92093

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES | 1996年 / 351卷 / 1336期

关键词：

JUN DNA-BINDING; C-JUN; PHORBOL ESTER; GENE-PRODUCT; MAP KINASES; PHOSPHORYLATION; DOMAIN; FOS; TRANSCRIPTION; ELEMENT;

D O I：

10.1098/rstb.1996.0008

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

AP-1 is a collection of dimeric sequence specific, DNA binding, transcriptional activators composed of Jun and Fos subunits. The composition, the level and the activity of AP-1 complexes are regulated in response to extracellular stimuli. An important role in this regulation is played by mitogen-activated protein kinases (MAPKs). The specific roles of three MAPKs, namely ERK, JNK and FRK, in modulation of both the level and activity of AP-1, are discussed.

引用

页码：127 / 134

页数：8

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