Primary hepatocytes as targets for Hepatitis C virus replication

被引：24

作者：

Farquhar, M. J. ^{[1
]}

McKeating, J. A. ^{[1
]}

机构：

[1] Univ Birmingham, Div Immun & Infect, Hepatitis C Res Grp, Birmingham B15 2TT, W Midlands, England

来源：

JOURNAL OF VIRAL HEPATITIS | 2008年 / 15卷 / 12期

基金：

英国医学研究理事会;

关键词：

hepatitis C; hepatocyte; internalization; lipoproteins; receptors;

D O I：

10.1111/j.1365-2893.2008.01051.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Much of our current understanding of hepatits C virus (HCV) replication has hailed from the use of a small number of cloned viral genomes and transformed hepatoma cell lines. Recent evidence suggests that lipoproteins play a key role in the HCV life cycle and virus particles derived from the sera of infected patients exist in association with host lipoproteins. This report will review the literature on HCV replication in primary hepatocytes and transformed cell lines, focusing largely on host factors defining particle entry.

引用

收藏

页码：849 / 854

页数：6

相关论文

共 66 条

[1]

Hepatitis C virus and other Flaviviridae viruses enter cells via low density lipoprotein receptor [J].

Agnello, V ;

Abel, G ;

Elfahal, M ;

Knight, GB ;

Zhang, QX .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (22) :12766-12771

[2]

Characterization of low- and very-low-density hepatitis C virus RNA-containing particles [J].

André, P ;

Komurian-Pradel, F ;

Deforges, S ;

Perret, M ;

Berland, JL ;

Sodoyer, M ;

Pol, S ;

Bréchot, C ;

Paranhos-Baccalà, G ;

Lotteau, V .

JOURNAL OF VIROLOGY, 2002, 76 (14) :6919-6928

[3]

Lipoprotein lipase mediates hepatitis C virus (HCV) cell entry and inhibits HCV infection [J].

Andreo, Ursula ;

Maillard, Patrick ;

Kalinina, Olga ;

Walic, Marine ;

Meurs, Eliane ;

Martinot, Michele ;

Marcellin, Patrick ;

Budkowska, Agata .

CELLULAR MICROBIOLOGY, 2007, 9 (10) :2445-2456

[4]

Novel insights into hepatitis C virus replication and persistence [J].

Bartenschlager, R ;

Frese, M ;

Pietschmann, T .

ADVANCES IN VIRUS RESEARCH, VOL. 63, 2004, 63 :71-+

[5]

An interplay between hypervariable region 1 of the Hepatitis C Virus E2 glycoprotein, the scavenger receptor BI, and high-density lipoprotein promotes both enhancement of infection and protection against neutralizing antibodies [J].

Bartosch, B ;

Verney, G ;

Dreux, M ;

Donot, P ;

Morice, Y ;

Penin, F ;

Pawlotsky, JM ;

Lavillette, D ;

Cosset, FL .

JOURNAL OF VIROLOGY, 2005, 79 (13) :8217-8229

[6]

Cell entry of hepatitis C virus requires a set of co-receptors that include the CD81 tetraspanin and the SR-B1 scavenger receptor [J].

Bartosch, B ;

Vitelli, A ;

Granier, C ;

Goujon, C ;

Dubuisson, J ;

Pascale, S ;

Scarselli, E ;

Cortese, R ;

Nicosia, A ;

Cosset, FL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (43) :41624-41630

[7]

Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes [J].

Bartosch, B ;

Dubuisson, J ;

Cosset, FL .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (05) :633-642

[8]

The hypervariable region 1 of the E2 glycoprotein of hepatitis C virus binds to glycosaminoglycans, but this binding does not lead to infection in a pseudotype system [J].

Basu, A ;

Beyene, A ;

Meyer, K ;

Ray, R .

JOURNAL OF VIROLOGY, 2004, 78 (09) :4478-4486

[9]

Different domains of CD81 mediate distinct stages of hepatitis C virus pseudoparticle entry [J].

Bertaux, Claire ;

Dragic, Tatjana .

JOURNAL OF VIROLOGY, 2006, 80 (10) :4940-4948

[10]

Alpha interferon inhibits hepatitis C virus replication in primary human hepatocytes infected in vitro [J].

Castet, V ;

Fournier, C ;

Soulier, A ;

Brillet, R ;

Coste, J ;

Larrey, D ;

Dhumeaux, D ;

Maurel, P ;

Pawlotsky, JM .

JOURNAL OF VIROLOGY, 2002, 76 (16) :8189-8199

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