Epstein-Barr virus growth/latency III program alters cellular microRNA expression

被引：123

作者：

Cameron, Jennifer E. ^{[1
,2
]}

Fewell, Claire ^{[3
]}

Yin, Qinyan ^{[1
,2
,3
]}

McBride, Jane ^{[3
]}

Wang, Xia ^{[3
]}

Lin, Zhen ^{[1
,2
,3
]}

Flemington, Erik K. ^{[1
,2
,3
]}

机构：

[1] Tulane Univ, Hlth Sci Ctr, Louisiana Canc Res Consortium, New Orleans, LA 70112 USA

[2] Tulane Univ, Hlth Sci Ctr, Tulane Canc Ctr, New Orleans, LA 70112 USA

[3] Tulane Univ, Hlth Sci Ctr, Dept Pathol, New Orleans, LA 70112 USA

来源：

VIROLOGY | 2008年 / 382卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Epstein-Barr virus; EBV; miRNA; Microrna; Latency; miR-21; miR-23a cluster; miR-23a; miR-24; miR-27a; miR-28; miR-34a; miR-146; miR-155;

D O I：

10.1016/j.virol.2008.09.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The Epstein-Barr Virus (EBV) is associated with lymphoid and epithelial cancers. Initial EBV infection alters lymphocyte gene expression, inducing cellular proliferation and differentiation as the virus transitions through consecutive latency transcription programs. Cellular microRNAs (miRNAs) are important regulators of signaling pathways and are implicated in carcinogenesis. The extent to which EBV exploits cellular miRNAs is unknown. Using micro-array analysis and quantitative PCR, we demonstrate differential expression of cellular miRNAs in type III versus type I EBV latency including elevated expression of miR-21, miR-23a, miR-24, miR-27a, miR-34a, miR-146a and b, and miR-155. In contrast, miR-28 expression was found to be lower ill type III latency. The EBV-mediated regulation Of cellular miRNAs may contribute to EBV signaling and associated cancers. (C) 20108 Elsevier Inc. All rights reserved.

引用

页码：257 / 266

页数：10

共 45 条

[1] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[2] EBV persistence in memory B cells in vivo [J].

Babcock, GJ ;

Decker, LL ;

Volk, M ;

Thorley-Lawson, DA .

IMMUNITY, 1998, 9 (03) :395-404

[3] A comparison of normalization methods for high density oligonucleotide array data based on variance and bias [J].

Bolstad, BM ;

Irizarry, RA ;

Åstrand, M ;

Speed, TP .

BIOINFORMATICS, 2003, 19 (02) :185-193

[4] Epstein-Barr virus MicroRNAs are evolutionarily conserved and differentially expressed [J].

Cai, Xuezhong ;

Schafer, Alexandra ;

Lu, Shihua ;

Bilello, John P. ;

Desrosiers, Ronald C. ;

Edwards, Rachel ;

Raab-Traub, Nancy ;

Cullen, Bryan R. .

PLOS PATHOGENS, 2006, 2 (03) :236-247

[5] MicroRNA signatures in human cancers [J].

Calin, George A. ;

Croce, Carlo M. .

NATURE REVIEWS CANCER, 2006, 6 (11) :857-866

[6] Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways [J].

Cameron, Jennifer E. ;

Yin, Qinyan ;

Fewell, Claire ;

Lacey, Michelle ;

McBride, Jane ;

Wang, Xia ;

Lin, Zhen ;

Schaefer, Brian C. ;

Flemington, Erik K. .

JOURNAL OF VIROLOGY, 2008, 82 (04) :1946-1958

[7] MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells [J].

Chan, JA ;

Krichevsky, AM ;

Kosik, KS .

CANCER RESEARCH, 2005, 65 (14) :6029-6033

[8] Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis [J].

Chang, Tsung-Cheng ;

Wentzel, Erik A. ;

Kent, Oliver A. ;

Ramachandran, Kalyani ;

Mullendore, Michael ;

Lee, Kwang Hyuck ;

Feldmann, Georg ;

Yamakuchi, Munekazu ;

Ferlito, Marcella ;

Lowenstein, Charles J. ;

Arking, Dan E. ;

Beer, Michael A. ;

Maitra, Anirban ;

Mendell, Joshua T. .

MOLECULAR CELL, 2007, 26 (05) :745-752

[9] Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in Eμ-miR155 transgenic mice [J].

Costinean, S ;

Zanesi, N ;

Pekarsky, Y ;

Tili, E ;

Volinia, S ;

Heerema, N ;

Croce, CM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (18) :7024-7029

[10] Accumulation of miR-155 and BIC RNA in human B cell lymphomas [J].

Eis, PS ;

Tam, W ;

Sun, LP ;

Chadburn, A ;

Li, ZD ;

Gomez, MF ;

Lund, E ;

Dahlberg, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (10) :3627-3632

← 1 2 3 4 5 →