Palladium-Catalyzed Direct C-4 Arylation of 2,5-Disubstituted Furans with Aryl Bromides

被引：67

作者：

Gottumukkala, Aditya L. ^{[1
]}

Doucet, Henri ^{[1
]}

机构：

[1] Univ Rennes Catalyse & Organomet, Inst Sci Chim Rennes, CNRS, UMR 6226, F-35042 Rennes, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2008年 / 350卷 / 14-15期

关键词：

aryl bromides; atom-economy; C-H bond activation; furans; palladium;

D O I：

10.1002/adsc.200800410

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A simple and atom-economic procedure for the selective C-4 arylation of 2,5-disubstituted furans via C-H bond activation using electron-deficient aryl bromides is reported. Only 0.5 mol% of the commercially available dimeric (allene)palladium chloride, [Pd(C3H5)Cl](2), was employed as catalyst. This environmentally attractive procedure has been found to be tolerant to a variety of functional groups on the aryl bromide such as carbonyl, nitrile, nitro, fluoro, ester or trifluoromethyl.

引用

页码：2183 / 2188

页数：6

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